Comparison of diets supplemented with fish oil or olive oil on plasma lipoproteins in insulin-dependent diabetics
Mori TA, Vandongen R, Masarei JR, Rouse IL, Dunbar D
Metabolism: clinical and experimental · 14 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1991-03-01 · Metabolism · vol. 40 · número 3 · págs. 241–246
- Editorial
- Elsevier BV
- Citado
- 22 citas · más que el 77% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health · Edible Oils Quality and Analysis
- Palabras clave
- fish oil supplementation, olive oil, type 1 diabetes, HDL2, HDL3 cholesterol, LDL cholesterol, eicosapentaenoic acid, omega-3 fatty acids, arachidonic acid, platelet membrane phospholipids, triglycerides, dietary cholesterol, serum lipoproteins
- MeSH
- humans, diabetes mellitus, type 1, cholesterol, dietary fats, unsaturated, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, triglycerides, lipoproteins, fish oils, plant oils, drug combinations, adult, male, cholesterol, ldl, cholesterol, hdl
5 autores
- Trevor Anthony Mori🇦🇺 · autor de correspondenciaRoyal Perth Hospital
- Robert Vandongen🇦🇺Royal Perth Hospital
- J.R.L. Masarei🇦🇺Royal Perth Hospital
- Ian L. Rouse🇦🇺Royal Perth Hospital
- D. Dunbar🇦🇺Royal Perth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study was designed to compare changes in high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol in normolipidaemic male insulin-dependent diabetics (IDD) following dietary supplementation with either the fish oil concentrate Max EPA or olive oil. The contribution of the small quantity of cholesterol in Max EPA to these changes was also examined. Twenty-seven subjects were matched in groups of three and randomly allocated to one of three treatment groups of nine subjects each. Subjects were given 15 1-g capsules of oil daily for 3 weeks, consisting of either Max EPA, olive oil, or olive oil to which was added the same amount of cholesterol as contained in Max EPA, respectively. There was a significant increase in eicosapentaenoic acid, and a decrease in arachidonic acid, in the platelet membrane phospholipids of subjects taking Max EPA. In this group, there was an approximately 30% increase in serum HDL2-cholesterol (0.59 +/- 0.07 to 0.77 +/- 0.11 mmol/L, mean +/- SEM; P less than .01) and a corresponding decrease in HDL3-cholesterol (0.79 +/- 0.03 to 0.71 +/- 0.03 mmol/L; P less than .05). Although total and LDL-cholesterol concentrations were also higher after Max EPA, the changes were not significant. Triglycerides were significantly decreased by Max EPA. There were no significant changes in lipids in the groups given olive oil. These results show that compared with olive oil, dietary supplementation with Max EPA substantially increases HDL2-cholesterol in insulin-dependent diabetics. This is most likely due to a selective effect of omega 3 fatty acids.(ABSTRACT TRUNCATED AT 250 WORDS)
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