Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis
Gao L, Tao Y, Zhang L, Jin Q
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 114 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-01-01 · Int J Tuberc Lung Dis · vol. 14 · número 1 · págs. 15–23
- Editorial
- National Institutes of Health
- Citado
- 161 citas · más que el 99% de estudios similares · 12.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Tuberculosis Research and Epidemiology · Vitamin D Research Studies · Genetic Associations and Epidemiology
- Palabras clave
- vitamin D receptor, VDR polymorphisms, tuberculosis susceptibility, host genetic susceptibility, FokI polymorphism, TaqI polymorphism, ApaI polymorphism, BsmI polymorphism, vitamin D deficiency, ethnic differences in genetic association
- MeSH
- humans, tuberculosis, vitamin d deficiency, genetic predisposition to disease, receptors, calcitriol, risk factors, genotype, polymorphism, genetic, south america, asian people, black people
4 autores
- Lei Gao🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- YongLiu Tao
- L Zhang
- Q Jin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Host genetic susceptibility has been suggested as one of the most important explanations for inter-individual differences in tuberculosis (TB) risk. The vitamin D receptor (VDR) gene has been studied as a candidate locus due to genetic polymorphisms that affects the activity of the receptor and subsequent downstream vitamin D-mediated effects.
Methods
We reviewed published studies on VDR polymorphisms and TB susceptibility up to 15 April 2009 and quantitatively summarised associations of the most widely studied polymorphisms (FokI, TaqI, ApaI and BsmI) using meta-analysis.
Results
A total of 23 eligible studies were included in this review. Heterogeneous results were observed, which may be partly explained by the differences between populations. Among Asians, the FokI ff genotype showed a pronounced positive association (OR 2.0, 95%CI 1.3-3.2), a significant inverse association was observed for the BsmI bb genotype (OR 0.5, 95%CI 0.4-0.8), and marginal significant associations were found for TaqI and ApaI polymorphisms. However, none of the polymorphisms was significantly related to TB among Africans or South Americans.
Conclusions
The association of VDR polymorphisms with risk of TB observed in our analyses supports the hypothesis that vitamin D deficiency might play a role as risk factor during the development of TB.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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