Effects of oral creatine and resistance training on serum myostatin and GASP-1
Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K
Molecular and cellular endocrinology · 63 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-12-23 · Mol Cell Endocrinol · vol. 317 · número 1-2 · págs. 25–30
- Editorial
- Elsevier BV
- Citado
- 92 citas · más que el 77% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Exercise and Physiological Responses
- Palabras clave
- creatine supplementation, resistance training, myostatin, skeletal muscle mass, muscle strength, lean body mass, muscle growth, serum biomarkers, body composition
- MeSH
- humans, creatine, intercellular signaling peptides and proteins, proteins, vesicular transport proteins, diet, administration, oral, body composition, dietary supplements, male, muscle strength, resistance training, myostatin, young adult
6 autores
- Abbas Saremi🇮🇷Arak University
- Reza Gharakhanloo🇮🇷Tarbiat Modares University
- Sasan Sharghi🇮🇷Tehran University of Medical Sciences
- M.R. Gharaati🇮🇷Tarbiat Modares University
- Bagher A. Larijani🇮🇷Tehran University of Medical Sciences
- Kobra Omidfar🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine the effect of resistance training for 8 weeks in conjunction with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and growth and differentiation factor-associated serum protein-1 (GASP-1). In a double-blinded design 27 healthy male subjects (23.42+/-2.2 years) were assigned to control (CON), resistance training+placebo (RT+PL) and resistance training+creatine supplementation (RT+CR) groups. The protocol consisted of 3 days per week of training for 8 weeks, each session including three sets of 8-10 repetitions at 60-70% of 1 RM for whole-body exercise. Blood sampling, muscular strength testing and body composition analysis (full body DEXA) were performed at 0, 4th and 8th weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease in serum levels of myostatin and increase in that of GASP-1. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (p0.05). The effects of resistance training on serum levels of myostatin and GASP-1, may explain the increased muscle mass that is amplified by creatine supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.