Optimization of insulin-mediated creatine retention during creatine feeding in humans
Pittas G, Hazell MD, Simpson EJ, Greenhaff PL
Journal of sports sciences · 8 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-12-23 · J Sports Sci · vol. 28 · número 1 · págs. 67–74
- Editorial
- Taylor & Francis
- Citado
- 15 citas · más que el 57% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Animal Nutrition and Physiology
- Palabras clave
- creatine supplementation, insulin secretion, essential amino acids, leucine, phenylalanine, protein hydrolysates, D-glucose, carbohydrate intake, plasma creatine, nasogastric tube feeding
- MeSH
- humans, creatine, insulin, dietary carbohydrates, glucose, amino acids, dietary proteins, cross-over studies, double-blind method, reference values, adult, male, young adult
4 autores
- George Pittas🇬🇧 · autor de correspondenciaUniversity of Nottingham; Queen's Medical Centre
- M. Hazell🇬🇧University of Nottingham
- Elizabeth J. Simpson🇬🇧University of Nottingham
- Paul Leonard Greenhaff🇬🇧University of Nottingham
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of this study was to determine whether creatine ingested in combination with relatively small quantities of essential amino acids, simple sugars, and protein would stimulate insulin release and augment whole-body creatine retention to the same extent as a large bolus of simple sugars. Seven young, healthy males underwent three randomized, 3-day experimental trials. Each day, 24-h urine collections were made, and on the second day participants received 5 g creatine + water (creatine trial), 5 g creatine + approximately 95 g dextrose (creatine + carbohydrate) or 5 g creatine + 14 g protein hydrolysate, 7 g leucine, 7 g phenylalanine, and 57 g dextrose (creatine + protein, amino acids, and carbohydrate) via naso-gastric tube at three equally spaced intervals. Blood samples were collected at predetermined intervals after the first and third naso-gastric bolus. After administration of the first and third bolus, serum insulin concentration was increased by 15 min (P < 0.05) in the creatine + carbohydrate and creatine + protein, amino acids, and carbohydrate trials compared with creatine alone, and plasma creatine increased more following creatine alone (15 min, P < 0.05) than in the creatine + carbohydrate and creatine + protein, amino acids, and carbohydrate trials. Urinary creatine excretion was greater with creatine alone (P < 0.05) than with creatine + carbohydrate and creatine + protein, amino acids, and carbohydrate. Administration of creatine + protein, amino acids, and carbohydrate can stimulate insulin release and augment whole-body creatine retention to the same extent as when larger quantities of simple sugars are ingested.
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