Blueberry supplementation improves memory in older adults
Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA
Journal of agricultural and food chemistry · 340 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (R21AG024484)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-01-04 · J Agric Food Chem · vol. 58 · número 7 · págs. 3996–4000
- Editorial
- American Chemical Society
- Citado
- 580 citas · más que el 100% de estudios similares · 101.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Medicinal Plants and Neuroprotection · Neurological Disease Mechanisms and Treatments · Biochemical Analysis and Sensing Techniques
- Palabras clave
- Neurocognitive, Dementia, Placebo, Medicine, Population, Neurodegeneration, Recall, Cognition, Psychology, Internal medicine, Environmental health, Psychiatry
- MeSH
- humans, plant extracts, memory, dietary supplements, aged, aged, 80 and over, female, male, blueberry plants
7 autores
- Robert Krikorian🇺🇸 · autor de correspondenciaUniversity of Cincinnati; University of Cincinnati Medical Center
- Marcelle D. Shidler🇺🇸University of Cincinnati; University of Cincinnati Medical Center
- Tiffany A. Nash🇺🇸University of Cincinnati; University of Cincinnati Medical Center
- Wilhelmina Kalt🇨🇦Agriculture and Agri-Food Canada
- Melinda R. Vinqvist🇨🇦Agriculture and Agri-Food Canada
- Barbara Shukitt‐Hale🇺🇸Tufts University
- James A. Joseph🇺🇸Tufts University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The prevalence of dementia is increasing with expansion of the older adult population. In the absence of effective therapy, preventive approaches are essential to address this public health problem. Blueberries contain polyphenolic compounds, most prominently anthocyanins, which have antioxidant and anti-inflammatory effects. In addition, anthocyanins have been associated with increased neuronal signaling in brain centers, mediating memory function as well as improved glucose disposal, benefits that would be expected to mitigate neurodegeneration. This study investigated the effects of daily consumption of wild blueberry juice in a sample of nine older adults with early memory changes. At 12 weeks, improved paired associate learning (p = 0.009) and word list recall (p = 0.04) were observed. In addition, there were trends suggesting reduced depressive symptoms (p = 0.08) and lower glucose levels (p = 0.10). We also compared the memory performances of the blueberry subjects with a demographically matched sample who consumed a berry placebo beverage in a companion trial of identical design and observed comparable results for paired associate learning. The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.