Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial
Fedirko V, Bostick RM, Long Q, Flanders WD, McCullough ML, Sidelnikov E, Daniel CR, Rutherford RE, Shaukat A
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 119 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Georgia Cancer Coalition
- Universidad u hospital
- Emory University
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R03CA136113); National Cancer Institute (R01CA104637)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2010-01-01 · Cancer Epidemiol Biomarkers Prev · vol. 19 · número 1 · págs. 280–291
- Editorial
- American Association for Cancer Research
- Citado
- 150 citas · más que el 98% de estudios similares · 9.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Antioxidant Activity and Oxidative Stress · Nutritional Studies and Diet
- Palabras clave
- vitamin D3, calcium supplementation, oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, colorectal mucosa, vitamin D receptor, colorectal adenoma, colorectal cancer chemoprevention, oxidative stress, DNA damage biomarkers
- MeSH
- intestinal mucosa, humans, adenoma, intestinal neoplasms, precancerous conditions, dna damage, calcium carbonate, calcium, dietary, cholecalciferol, deoxyguanosine, immunohistochemistry, pilot projects, double-blind method, oxidative stress, dietary supplements, image processing, computer-assisted, adult, aged, middle aged, female, male, biomarkers, tumor, 8-hydroxy-2'-deoxyguanosine
9 autores
- Veronika Fedirko🇺🇸American Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Roberd M. Bostick🇺🇸 · autor de correspondenciaAmerican Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Qi Long🇺🇸American Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Division of Cancer Epidemiology and Genetics
- W. Dana Flanders🇺🇸American Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Marjorie L. McCullough🇺🇸American Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Winship Cancer Institute; Division of Cancer Epidemiology and Genetics
- Eduard Sidelnikov🇺🇸American Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Carrie R. Daniel🇺🇸American Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Winship Cancer Institute; Division of Cancer Epidemiology and Genetics
- Robin E. Rutherford🇺🇸American Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Winship Cancer Institute; Division of Cancer Epidemiology and Genetics
- Aasma Shaukat🇺🇸American Cancer Society; University of Minnesota; Emory University; National Cancer Institute; Winship Cancer Institute; Division of Cancer Epidemiology and Genetics
Resumen
El texto original del estudio, en el idioma en que se publicó.
The exact antineoplastic effects of calcium and vitamin D(3) in the human colon are unclear. Animal and in vitro studies show that these two agents reduce oxidative stress; however, these findings have never been investigated in humans. To address this, we conducted a pilot, randomized, double-blind, placebo-controlled, 2 x 2 factorial clinical trial to test the effects of calcium and vitamin D(3) on a marker of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine (8-OH-dG), in the normal colorectal mucosa. Patients (N = 92) with at least one pathology-confirmed colorectal adenoma were treated with 2 g/d calcium and/or 800 IU/d vitamin D(3) versus placebo over 6 months. Overall labeling and colorectal crypt distribution of 8-OH-dG in biopsies of normal-appearing rectal mucosa were detected by standardized automated immunohistochemistry and quantified by image analysis. After 6 months of treatment, 8-OH-dG labeling along the full lengths of colorectal crypts decreased by 22% (P = 0.15) and 25% (P = 0.10) in the calcium and vitamin D(3) groups, respectively, but not in the calcium plus vitamin D(3) group. The estimated treatment effects were strongest among participants with higher baseline colon crypt vitamin D receptor expression (P = 0.05). Overall, these preliminary results indicate that calcium and vitamin D(3) may decrease oxidative DNA damage in the normal human colorectal mucosa, support the hypothesis that 8-OH-dG labeling in colorectal crypts is a treatable oxidative DNA damage biomarker of risk for colorectal neoplasms, and provide support for further investigation of calcium and vitamin D(3) as chemopreventive agents against colorectal neoplasms.
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