Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats
Paul S, DeCastro AJ, Lee HJ, Smolarek AK, So JY, Simi B, Wang CX, Zhou R, Rimando AM, Suh N
Carcinogenesis · 104 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Universidad u hospital
- Rutgers, The State University of New Jersey
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIEHS NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (P-30 ES-005022)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-01-08 · Carcinogenesis · vol. 31 · número 7 · págs. 1272–1278
- Editorial
- Oxford University Press
- Citado
- 128 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Sirtuins and Resveratrol in Medicine · Cancer-related molecular mechanisms research · RNA modifications and cancer
- Palabras clave
- Pterostilbene, Azoxymethane, Carcinogenesis, Proinflammatory cytokine, Resveratrol, Cyclin D1, Cancer research, Aberrant crypt foci, Tumor necrosis factor alpha, Chemistry, Apoptosis, Cell cycle, Biology, Internal medicine, Biochemistry, Inflammation, Endocrinology, Immunology, Colorectal cancer, Medicine, Cancer
- MeSH
- ht29 cells, animals, rats, inbred f344, humans, rats, colonic neoplasms, azoxymethane, stilbenes, cyclin d1, proto-oncogene proteins c-myc, proliferating cell nuclear antigen, cytokines, signal transduction, phosphorylation, male, beta catenin, cyclooxygenase 2, transcription factor rela, nitric oxide synthase type ii
10 autores
- Sattwikesh Paul🇺🇸Rutgers, The State University of New Jersey; Environmental and Occupational Health Sciences Institute
- Andrew DeCastro🇺🇸Rutgers, The State University of New Jersey
- H. J. Lee🇺🇸Rutgers, The State University of New Jersey
- Amanda K. Smolarek🇺🇸Rutgers, The State University of New Jersey
- Jae Young So🇺🇸Rutgers, The State University of New Jersey
- Barbara Simi🇺🇸Rutgers, The State University of New Jersey
- C-X Wang🇺🇸Rutgers, The State University of New Jersey
- Renping Zhou🇺🇸Rutgers, The State University of New Jersey
- Agnes M. Rimando🇺🇸Rutgers, The State University of New Jersey
- Nanjoo Suh🇺🇸Rutgers, The State University of New Jersey
Resumen
El texto original del estudio, en el idioma en que se publicó.
Stilbenes are phytochemicals present in grapes, berries, peanuts and red wine. A widely studied stilbene, resveratrol (trans-3,5,4'-trihydroxystilbene), has been shown to exert antioxidant, anti-inflammatory, chemopreventive and antiaging effects in a number of biological systems. We reported earlier that pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene), a structurally related stilbene found in blueberries, was effective in reducing the incidence and multiplicity of aberrant crypt foci formation in the colon of rats injected with azoxymethane (AOM). Our present study was to identify the chemopreventive potential of pterostilbene with colonic tumor formation as an end point and further to evaluate the mechanistic action of pterostilbene during colon carcinogenesis. F344 rats were given two AOM injections subcutaneously when they were 7 and 8 weeks old and continuously fed the control or 40 p.p.m. pterostilbene diet for 45 weeks. Overall analyses indicated that pterostilbene reduced colon tumor multiplicity of non-invasive adenocarcinomas, lowered proliferating cell nuclear antigen and downregulated the expression of beta-catenin and cyclin D1. Pterostilbene decreased mucosal levels of the proinflammatory cytokines, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-4. Colon tumors from pterostilbene-fed animals showed reduced expression of inflammatory markers as well as nuclear staining for phospho-p65, a key molecule in the nuclear factor-kappaB pathway. In HT-29 cells, pterostilbene reduced the protein levels of beta-catenin, cyclin D1 and c-MYC, altered the cellular localization of beta-catenin and inhibited the phosphorylation of p65. Our data with pterostilbene in suppressing colon tumorigenesis, cell proliferation as well as key inflammatory markers in vivo and in vitro suggest the potential use of pterostilbene for colon cancer prevention.
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