Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
Siri-Tarino PW, Sun Q, Hu FB, Krauss RM
The American journal of clinical nutrition · 678 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL60712); National Center for Research Resources (UL1RR024131); National Center for Research Resources (RR 024131); National Center for Research Resources (RR02413101); National Institutes of Health (RR024131); National Institutes of Health (HL 60712)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2010-01-13 · Am J Clin Nutr · vol. 91 · número 3 · págs. 535–546
- Editorial
- Elsevier BV
- Citado
- 1,256 citas · más que el 100% de estudios similares · 13.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Fatty Acid Research and Health · Cardiovascular Health and Risk Factors
- Palabras clave
- dietary saturated fat, cardiovascular disease, coronary artery disease, stroke, saturated fat intake, prospective cohort, relative risk, saturated fat replacement
- MeSH
- humans, cardiovascular diseases, coronary disease, dietary fats, fatty acids, diet, risk factors, cohort studies, prospective studies, stroke
4 autores
- Patty W. Siri‐Tarino
- Qi Sun🇺🇸Harvard University
- Frank B. Hu🇺🇸Harvard University
- Ronald M. Krauss🇺🇸 · autor de correspondenciaHarvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A reduction in dietary saturated fat has generally been thought to improve cardiovascular health.
Objective
The objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies.
Design
Twenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualified for inclusion in this study. A random-effects model was used to derive composite relative risk estimates for CHD, stroke, and CVD.
Results
During 5-23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an increased risk of CHD, stroke, or CVD. The pooled relative risk estimates that compared extreme quantiles of saturated fat intake were 1.07 (95% CI: 0.96, 1.19; P = 0.22) for CHD, 0.81 (95% CI: 0.62, 1.05; P = 0.11) for stroke, and 1.00 (95% CI: 0.89, 1.11; P = 0.95) for CVD. Consideration of age, sex, and study quality did not change the results.
Conclusions
A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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