Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial
Barbosa VM, Miles EA, Calhau C, Lafuente E, Calder PC
Critical care (London, England) · 119 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2010-01-19 · Crit Care · vol. 14 · número 1 · pág. R5
- Editorial
- BioMed Central
- Citado
- 180 citas · más que el 99% de estudios similares · 15.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Sepsis Diagnosis and Treatment
- Palabras clave
- fish oil, lipid emulsions, sepsis, parenteral nutrition, phospholipid fatty acids, eicosapentaenoic acid, phosphatidylcholine, interleukin-6, IL-10, inflammatory cytokines, eicosanoids, lipopolysaccharide stimulation, oxygenation, length of hospital stay, mortality
- MeSH
- humans, sepsis, fatty acids, omega-3, soybean oil, phospholipids, fish oils, inflammation mediators, emulsions, treatment outcome, length of stay, single-blind method, aged, aged, 80 and over, middle aged, female, male
5 autores
- Vera M Barbosa🇬🇧Southampton General Hospital; University of Southampton
- Elizabeth A. Miles🇬🇧Southampton General Hospital; University of Southampton
- Conceição Calhau🇵🇹Universidade do Porto
- Estevão Lafuente🇵🇹Hospital Padre Américo
- Philip C. Calder🇬🇧 · autor de correspondenciaSouthampton General Hospital; University of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
The effect of parenteral fish oil in septic patients is not widely studied. This study investigated the effects of parenteral fish oil on plasma phospholipid fatty acids, inflammatory mediators, and clinical outcomes.
Methods
Twenty-five patients with systemic inflammatory response syndrome or sepsis, and predicted to need parenteral nutrition were randomized to receive either a 50:50 mixture of medium-chain fatty acids and soybean oil or a 50:40:10 mixture of medium-chain fatty acids, soybean oil and fish oil. Parenteral nutrition was administrated continuously for five days from admission. Cytokines and eicosanoids were measured in plasma and in lipopolysaccharide-stimulated whole blood culture supernatants. Fatty acids were measured in plasma phosphatidylcholine.
Results
Fish oil increased eicosapentaenoic acid in plasma phosphatidylcholine (P < 0.001). Plasma interleukin (IL)-6 concentration decreased significantly more, and IL-10 significantly less, in the fish oil group (both P < 0.001). At Day 6 the ratio PO2/FiO2 was significantly higher in the fish oil group (P = 0.047) and there were fewer patients with PO2/FiO2 <200 and <300 in the fish oil group (P = 0.001 and P = 0.015, respectively). Days of ventilation, length of intensive care unit (ICU) stay and mortality were not different between the two groups. The fish oil group tended to have a shorter length of hospital stay (22 +/- 7 vs. 55 +/- 16 days; P = 0.079) which became significant (28 +/- 9 vs. 82 +/- 19 days; P = 0.044) when only surviving patients were included.
Conclusions
Inclusion of fish oil in parenteral nutrition provided to septic ICU patients increases plasma eicosapentaenoic acid, modifies inflammatory cytokine concentrations and improves gas exchange. These changes are associated with a tendency towards shorter length of hospital stay.
Trials registration
Clinical Trials Registration Number ISRCTN89432944.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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