Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma: a randomized placebo controlled trial
Kazaks AG, Uriu-Adams JY, Albertson TE, Shenoy SF, Stern JS
The Journal of asthma : official journal of the Association for the Care of Asthma · 37 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of California, Davis
- Gobierno
- National Center for Complementary and Integrative Health
- Gobierno
- NCCIH NIH HHS
- Subvenciones
- National Center for Complementary and Integrative Health (R01 AT000652-02)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2010-01-25 · J Asthma · vol. 47 · número 1 · págs. 83–92
- Editorial
- Taylor & Francis
- Citado
- 72 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Asthma and respiratory diseases · Magnesium in Health and Disease · Magnesium Alloys: Properties and Applications
- Palabras clave
- magnesium supplementation, asthma, airway resistance, asthma control, quality of life, methacholine challenge, airway hyperresponsiveness, peak expiratory flow, dietary magnesium, exhaled nitric oxide, C-reactive protein
- MeSH
- erythrocytes, humans, asthma, bronchial hyperreactivity, inflammation, magnesium, nitric oxide, c-reactive protein, placebos, breath tests, airway resistance, bronchial provocation tests, vital capacity, peak expiratory flow rate, forced expiratory volume, treatment outcome, quality of life, dietary supplements, adult, middle aged, female, male, young adult
5 autores
- Alexandra Kazaks🇺🇸 · autor de correspondenciaBastyr University
- Janet Y. Uriu‐Adams🇺🇸University of California, Davis
- Timothy E. Albertson🇺🇸University of California, Davis
- Sonia F Shenoy🇺🇸University of California, Davis
- Judith S. Stern
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological data shows low dietary magnesium(Mg) may be related to incidence and progression of asthma.
Objective
To determine if long term(6.5 month) treatment with oral Mg would improve asthma control and increase serum measures of Mg status in men and women with mild-to-moderate asthma.
Subjects
55 males and females aged 21 to 55 years with mild to moderate asthma according to the 2002 National Heart, Lung, and Blood Institute(NHLBI) and Asthma Education and Prevention Program(NAEPP) guidelines and who used only beta-agonists or inhaled corticosteroids(ICS) as asthma medications were enrolled.
Design
Subjects were randomly assigned to consume 340 mg(170 mg twice a day) of Mg or a placebo for 6.5 months.
Measurements
Multiple measures of Mg status including serum, erythrocyte, urine, dietary, ionized and IV Mg were measured.
Objective
markers of asthma control were: methacholine challenge test(MCCT) and pulmonary function test(PFT) results. Subjective validated questionnaires on asthma quality of life(AQLQ) and control(ACQ) were completed by participants. Markers of inflammation, including c-reactive protein(CRP) and exhaled nitric oxide(eNO) were determined.
Results
The concentration of methacholine required to cause a 20% drop in forced expiratory volume in in minute(FEV(1)) increased significantly from baseline to month 6 within the Mg group. Peak expiratory flow rate(PEFR) showed a 5.8% predicted improvement over time(P = 0.03) in those consuming the Mg. There was significant improvement in AQLQ mean score units(P < 0.01) and in overall ACQ score only in the Mg group(P = 0.05) after 6.5 months of supplementation. Despite these improvements, there were no significant changes in any of the markers of Mg status.
Conclusion
Adults who received oral Mg supplements showed improvement in objective measures of bronchial reactivity to methacholine and PEFR and in subjective measures of asthma control and quality of life.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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