The effects of vitamin D supplementation on physical function and quality of life in older patients with heart failure: a randomized controlled trial
Witham MD, Crighton LJ, Gillespie ND, Struthers AD, McMurdo ME
Circulation. Heart failure · 167 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Chief Scientist Office
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-01-27 · Circ Heart Fail · vol. 3 · número 2 · págs. 195–201
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 224 citas · más que el 99% de estudios similares · 14.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health in Aging · Hormonal and reproductive studies
- Palabras clave
- vitamin D supplementation, vitamin D insufficiency, heart failure, older adults, physical function, quality of life, 25-hydroxyvitamin D, exercise tolerance, 6-minute walk distance, brain natriuretic peptide, TNF-α, chronic inflammation, skeletal myopathy
- MeSH
- humans, vitamin d deficiency, natriuretic peptide, brain, vitamin d, placebos, treatment outcome, walking, activities of daily living, chi-square distribution, statistics, nonparametric, double-blind method, quality of life, aged, aged, 80 and over, female, male, heart failure, biomarkers, surveys and questionnaires
5 autores
- Miles D. Witham🇬🇧University of Dundee; Ninewells Hospital
- Linda J. Crighton🇬🇧University of Dundee; Ninewells Hospital
- Neil D. Gillespie🇬🇧University of Dundee; Ninewells Hospital
- Allan D. Struthers🇬🇧University of Dundee; Ninewells Hospital
- Marion E. T. McMurdo🇬🇧University of Dundee; Ninewells Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low 25-hydroxyvitamin D levels, commonly found in older patients with heart failure, may contribute to the chronic inflammation and skeletal myopathy that lead to poor exercise tolerance. We tested whether vitamin D supplementation of patients with heart failure and vitamin D insufficiency can improve physical function and quality of life.
Methods and results
In a randomized, parallel group, double-blind, placebo-controlled trial, patients with systolic heart failure aged >or=70 years with 25-hydroxyvitamin D levels <50 nmol/L (20 ng/mL) received 100,000 U of oral vitamin D2 or placebo at baseline and 10 weeks. Outcomes measured at baseline, 10 weeks, and 20 weeks were 6-minute walk distance, quality of life (Minnesota score), daily activity measured by accelerometry, Functional Limitations Profile, B-type natriuretic peptide, and tumor necrosis factor-alpha. Participants in the vitamin D group had an increase in their 25-hydroxyvitamin D levels compared with placebo at 10 weeks (22.9 versus 2.3 nmol/L [9.2 versus 0.9 ng/mL]; P<0.001) and maintained this increase at 20 weeks. The 6-minute walk did not improve in the treatment group relative to placebo. No significant benefit was seen on timed up and go testing, subjective measures of function, daily activity, or tumor necrosis factor. Quality of life worsened by a small, but significant amount in the treatment group relative to placebo. B-type natriuretic peptide decreased in the treatment group relative to placebo (-22 versus +78 pg/mL at 10 weeks; P=0.04).
Conclusions
Vitamin D supplementation did not improve functional capacity or quality of life in older patients with heart failure with vitamin D insufficiency. Clinical Trial Registration- www.controlled-trials.com. Identifier: ISRCTN51372896.
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