Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet
Hernandez TL, Sutherland JP, Wolfe P, Allian-Sauer M, Capell WH, Talley ND, Wyatt HR, Foster GD, Hill JO, Eckel RH
The American journal of clinical nutrition · 42 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (1UL1-RR-025780)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-01-28 · Am J Clin Nutr · vol. 91 · número 3 · págs. 578–585
- Editorial
- Elsevier BV
- Citado
- 60 citas · más que el 86% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Diet and metabolism studies · Dietary Effects on Health · Diet, Metabolism, and Disease
- Palabras clave
- weight loss, low-carbohydrate high-fat diet, low-carbohydrate diet, free fatty acids, hypercholesterolemia, LDL cholesterol, remnant cholesterol, triglycerides, insulin, obesity, caloric restriction
- MeSH
- humans, hypercholesterolemia, obesity, weight loss, insulin, dietary carbohydrates, dietary fats, fatty acids, nonesterified, triglycerides, lipoproteins, diet, fat-restricted, diet, reducing, energy intake, adult, middle aged, female, male, diet, carbohydrate-restricted, cholesterol, ldl
10 autores
- Teri L. Hernandez🇺🇸 · autor de correspondenciaUniversity of Colorado Denver
- Julie P. Sutherland🇺🇸Temple University
- Pamela Wolfe🇺🇸Temple University
- Marybeth U Allian-Sauer🇺🇸Temple University
- Warren H. Capell🇺🇸Temple University
- Natalie D Talley🇺🇸Temple University
- Holly Roxanna Wyatt🇺🇸Temple University
- Gary D. Foster🇺🇸Temple University
- James O. Hill🇺🇸Temple University
- Robert H. Eckel🇺🇸Temple University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Little is known about the comparative effect of weight-loss diets on metabolic profiles during dieting.
Objective
The purpose of this study was to compare the effect of a low-carbohydrate diet (< or =20 g/d) with a high-carbohydrate diet (55% of total energy intake) on fasting and hourly metabolic variables during active weight loss.
Design
Healthy, obese adults (n = 32; 22 women, 10 men) were randomly assigned to receive either a carbohydrate-restricted diet [High Fat; mean +/- SD body mass index (BMI; in kg/m(2)): 35.8 +/- 2.9] or a calorie-restricted, low-fat diet (High Carb; BMI: 36.7 +/- 4.6) for 6 wk. A 24-h in-patient feeding study was performed at baseline and after 6 wk. Glucose, insulin, free fatty acids (FFAs), and triglycerides were measured hourly during meals, at regimented times. Remnant lipoprotein cholesterol was measured every 4 h.
Results
Patients lost a similar amount of weight in both groups (P = 0.57). There was an absence of any diet treatment effect between groups on fasting triglycerides or on remnant lipoprotein cholesterol, which was the main outcome. Fasting insulin decreased (P = 0.03), and both fasting (P = 0.040) and 24-h FFAs (P < 0.0001) increased within the High Fat group. Twenty-four-hour insulin decreased (P < 0.05 for both groups). Fasting LDL cholesterol decreased in the High Carb group only (P = 0.003). In both groups, the differences in fasting and 24-h FFAs at 6 wk were significantly correlated with the change in LDL cholesterol (fasting FFA: r = 0.41, P = 0.02; 24-h FFA: r = 0.52, P = 0.002).
Conclusions
Weight loss was similar between diets, but only the high-fat diet increased LDL-cholesterol concentrations. This effect was related to the lack of suppression of both fasting and 24-h FFAs.
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