Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study
McNamara RK, Able J, Jandacek R, Rider T, Tso P, Eliassen JC, Alfieri D, Weber W, Jarvis K, DelBello MP, Strakowski SM, Adler CM
The American journal of clinical nutrition · 152 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Mental Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIMH NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 59630); National Institute of Mental Health (MH 074858)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-02-04 · Am J Clin Nutr · vol. 91 · número 4 · págs. 1060–1067
- Editorial
- Elsevier BV
- Citado
- 213 citas · más que el 99% de estudios similares · 14.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Neural and Behavioral Psychology Studies
- Palabras clave
- docosahexaenoic acid, omega-3 fatty acids, dietary supplementation, sustained attention, dorsolateral prefrontal cortex, cerebellum, occipital cortex, reaction time, children, attentional networks, dose-response relationship
- MeSH
- cerebral cortex, prefrontal cortex, erythrocytes, humans, docosahexaenoic acids, magnetic resonance imaging, attention, reaction time, reference values, dietary supplements, child, male
12 autores
- Robert K. McNamara🇺🇸 · autor de correspondenciaUniversity of Cincinnati
- Jessica A. Able🇺🇸University of Cincinnati
- Ronald J. Jandacek🇺🇸University of Cincinnati
- Therese Rider🇺🇸University of Cincinnati
- Patrick Tso🇺🇸University of Cincinnati
- James C. Eliassen🇺🇸University of Cincinnati
- David C. Alfieri🇺🇸University of Cincinnati
- Wade Weber🇺🇸University of Cincinnati
- Kelly Jarvis🇺🇸University of Cincinnati
- Melissa P. DelBello🇺🇸University of Cincinnati
- Stephen M. Strakowski🇺🇸University of Cincinnati
- Caleb M. Adler🇺🇸University of Cincinnati
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Emerging evidence suggests that docosahexaenoic acid (DHA, 22:6n-3), the principal omega-3 (n-3) fatty acid in brain gray matter, positively regulates cortical metabolic function and cognitive development. However, the effects of DHA supplementation on functional cortical activity in human subjects are unknown.
Objective
The objective was to determine the effects of DHA supplementation on functional cortical activity during sustained attention in human subjects.
Design
Healthy boys aged 8-10 y (n = 33) were randomly assigned to receive placebo or 1 of 2 doses of DHA (400 or 1200 mg/d) for 8 wk. Relative changes in cortical activation patterns during sustained attention at baseline and endpoint were determined by functional magnetic resonance imaging.
Results
At 8 wk, erythrocyte membrane DHA composition increased significantly from baseline in subjects who received low-dose (by 47%) or high-dose (by 70%) DHA but not in those who received placebo (-11%). During sustained attention, both DHA dose groups had significantly greater changes from baseline in activation of the dorsolateral prefrontal cortex than did the placebo group, and the low-dose and high-dose DHA groups had greater decreases in the occipital cortex and cerebellar cortex, respectively. Relative to low-dose DHA, high-dose DHA resulted in greater decreases in activation of bilateral cerebellum. The erythrocyte DHA composition was positively correlated with dorsolateral prefrontal cortex activation and was inversely correlated with reaction time, at baseline and endpoint.
Conclusion
Dietary DHA intake and associated elevations in erythrocyte DHA composition are associated with alterations in functional activity in cortical attention networks during sustained attention in healthy boys. This trial was registered at clinicaltrials.gov as NCT00662142.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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