The effects of two nights of sleep deprivation with or without energy restriction on immune indices at rest and in response to cold exposure
Costa RJ, Smith AH, Oliver SJ, Walters R, Maassen N, Bilzon JL, Walsh NP
European journal of applied physiology · 22 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-02-05 · Eur J Appl Physiol · vol. 109 · número 3 · págs. 417–428
- Editorial
- Springer Science+Business Media
- Citado
- 33 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Sleep and Work-Related Fatigue · Sleep and Wakefulness Research · Circadian rhythm and melatonin
- Palabras clave
- sleep deprivation, caloric restriction, cold exposure, immune function, neutrophil degranulation, secretory IgA, cortisol, norepinephrine, epinephrine, lymphocyte count, neutrophilia, whole-body cooling, stress hormones, immune indices, thermoregulation, sleep and immunity, immunosenescence
- MeSH
- neutrophils, saliva, humans, sleep deprivation, body weight, epinephrine, norepinephrine, hydrocortisone, blood glucose, immunoglobulin a, secretory, monitoring, immunologic, leukocyte count, caloric restriction, hypothermia, induced, motor activity, cell degranulation, plasma volume, time factors, adult, male, stress, physiological, young adult
7 autores
- Ricardo J. S. Costa🇬🇧Bangor University
- Adam Harper Smith🇬🇧Bangor University
- Samuel James Oliver🇬🇧Bangor University
- Robert L. Walters🇬🇧Ysbyty Gwynedd Hospital NHS Trust
- Norbert Maassen🇩🇪Medizinische Hochschule Hannover
- James Bilzon🇬🇧University of Bath
- Neil P. Walsh🇬🇧 · autor de correspondenciaBangor University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of the study was to determine the effects of two nights of sleep deprivation with or without energy restriction on immune indices at rest and in response to cold exposure. On three randomised occasions ten males slept normally [mean (SD): 436 (21) min night(-1); CON], were totally sleep-deprived (SDEP), or were totally sleep-deprived and 90% energy-restricted (SDEP + ER) for 53 h. After 53 h (1200 h) participants performed a seated cold air test (CAT) at 0.0 degrees C until T (re) decreased to 36.0 degrees C. Circulating leucocyte counts, neutrophil degranulation, stress hormones and saliva secretory IgA (S-IgA) were determined at 0 h, 24 h, 48 h, pre-CAT, post-CAT, 1-h and 2-h post-CAT. One night on SDEP increased bacterially stimulated neutrophil degranulation (21%, P < 0.05), and two nights on SDEP and SDEP + ER increased S-IgA concentration (40 and 44%; P < 0.01). No other significant effects were observed for immuno-endocrine measures prior to CAT. CAT duration was not different between trials [mean (SD): 133 (53) min] and T (re) decreased to 35.9 (0.3) degrees C. Modest whole-body cooling decreased circulating lymphocyte counts (25%; P < 0.01), S-IgA concentration (36%; P < 0.01) and secretion rate (24%; P < 0.05). A neutrophilia occurred post-CAT on CON and SDEP and 2-h post-CAT on SDEP + ER (P < 0.01). Modest whole-body cooling also decreased neutrophil degranulation on CON (22%) and SDEP (18%; P < 0.05). Plasma cortisol and norepinephrine increased post-CAT (31 and 346%, P < 0.05), but modest whole-body cooling did not alter plasma epinephrine. In conclusion, two nights of SDEP or SDEP + ER did not compromise resting immune indices. However, modest whole-body cooling (T(re) 35.9 degrees C) decreased circulating lymphocytes, neutrophil degranulation and S-IgA, but responses were not amplified by prior SDEP or SDEP + ER.
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