Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet
Prior RL, E Wilkes S, R Rogers T, Khanal RC, Wu X, Howard LR
Journal of agricultural and food chemistry · 136 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-02-11 · J Agric Food Chem · vol. 58 · número 7 · págs. 3970–3976
- Editorial
- American Chemical Society
- Citado
- 222 citas · más que el 99% de estudios similares · 11.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Biochemical Analysis and Sensing Techniques · Phytochemicals and Antioxidant Activities · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Adipose tissue, Sucrose, Chemistry, Blowing a raspberry, Obesity, Leptin, Food science, Biology, Animal science, Endocrinology, Biochemistry
- MeSH
- adipose tissue, animals, mice, inbred c57bl, humans, mice, obesity, disease models, animal, anthocyanins, leptin, blood glucose, dietary fats, plant extracts, beverages, male, blueberry plants
6 autores
- Ronald L. Prior🇺🇸 · autor de correspondenciaUnited States Department of Agriculture; Arkansas Children's Nutrition Center
- Samuel E. Wilkes🇺🇸Arkansas Children's Nutrition Center
- Theodore R. Rogers🇺🇸Arkansas Children's Nutrition Center
- Ramesh C. Khanal🇺🇸Arkansas Children's Nutrition Center; University of Arkansas at Fayetteville
- Xianli Wu🇺🇸Arkansas Children's Nutrition Center; University of Arkansas for Medical Sciences
- Luke R. Howard🇺🇸University of Arkansas at Fayetteville
Resumen
El texto original del estudio, en el idioma en que se publicó.
Male C57BL/6J mice (25 days of age) were fed either a low-fat diet (10% kcal from fat) (LF) or a high-fat diet (45% kcal from fat) (HF45) for a period of 72 days. Blueberry juice or purified blueberry anthocyanins (0.2 or 1.0 mg/mL) in the drinking water were included in LF or HF45 treatments. Sucrose was added to the drinking water of one treatment to test if the sugars in blueberry juice would affect development of obesity. Total body weights (g) and body fat (%) were higher and body lean tissue (%) was lower in the HF45 fed mice compared to the LF fed mice after 72 days, but in mice fed HF45 diet plus blueberry juice or blueberry anthocyanins (0.2 mg/mL), body fat (%) was not different from those mice fed the LF diet. Anthocyanins (ACNs) decreased retroperitoneal and epididymal adipose tissue weights. Fasting serum glucose concentrations were higher in mice fed the HF45 diet. However, it was reduced to LF levels in mice fed the HF45 diet plus 0.2 mg of ACNs/mL in the drinking water, but not with blueberry juice. beta cell function (HOMA-BCF) score was lowered with HF45 feeding but returned to normal levels in mice fed the HF45 diet plus purified ACNs (0.2 mg/mL). Serum leptin was elevated in mice fed HF45 diet, and feeding either blueberry juice or purified ACNs (0.2 mg/mL) decreased serum leptin levels relative to HF45 control. Sucrose in drinking water, when consumption was restricted to the volume of juice consumed, produced lower serum leptin and insulin levels, leptin/fat, and retroperitoneal and total fat (% BW). Blueberry juice was not as effective as the low dose of anthocyanins in the drinking water in preventing obesity. Additional studies are needed to determine factors responsible for the differing responses of blueberry juice and whole blueberry in preventing the development of obesity.
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