Creatine phosphate (Neoton) as an additive to St. Thomas' Hospital cardioplegic solution (Plegisol). Results of a clinical study
Chambers DJ, Braimbridge MV, Kosker S, Yamada M, Jupp RA, Crowther A
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 7 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1991-01-01 · Eur J Cardiothorac Surg · vol. 5 · número 2 · págs. 74–81
- Editorial
- Oxford University Press
- Citado
- 17 citas · más que el 88% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 18 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiac and Coronary Surgery Techniques · Cardiac Ischemia and Reperfusion · Transplantation: Methods and Outcomes
- Palabras clave
- phosphocreatine, cardioplegia, St. Thomas' Hospital cardioplegic solution, cardioprotection, coronary artery bypass grafting, reperfusion arrhythmias, creatine kinase-MB, myocardial infarction, postoperative cardiac function, birefringence, inotropic support
- MeSH
- myocardium, aorta, heart valves, humans, myocardial reperfusion injury, calcium chloride, bicarbonates, potassium chloride, sodium chloride, magnesium, isoenzymes, creatine kinase, phosphocreatine, cardioplegic solutions, electrocardiography, heart arrest, induced, coronary artery bypass, time factors, adult, aged, middle aged, arrhythmias, cardiac
6 autores
- David J. Chambers
- M.V. Braimbridge
- S KOSKER
- Muneaki Yamada
- R A Jupp
- A. Crowther
Resumen
El texto original del estudio, en el idioma en que se publicó.
Experimentally, creatine phosphate (CP) added to St. Thomas' Hospital cardioplegic solution (STH) improved post-ischaemic recovery of cardiac function in the rat heart. We investigated the effect of adding CP (10.0 mmol/l) to STH. Fifty open-heart surgery patients were randomized into control (STH) and treated (STH + CP) groups (25 per group). Patients underwent (a) monitoring for peri- and postoperative arrhythmias (48-h Holter monitoring). (b) quantitative birefringence assessment of intraoperative myocardial protection in left and right ventricular biopsies sampled at start of bypass (pre-isch.), end of bypass (end-isch.) and after 10 min reperfusion (post-isch.), and (c) measurement of serum creatine kinase-MB isozyme (CK-MB) values for up to 4 days postoperatively; results were assessed with respect to (d) haemodynamics and postoperative clinical outcome. Inotropic support (adrenaline) was required in three patients (12%) from each group; no patient died. All patients required defibrillation, and the number of direct current shocks required for sinus rhythm was the same in each group. The occurrence and incidence of reperfusion-induced arrhythmias were the same in both groups. Serum CK and CK-MB values were similar throughout the sampling period in both groups of patients; one patient in the control group had raised CK-MB levels postoperatively, but perioperative infarction was not indicated by the electrocardiogram.(ABSTRACT TRUNCATED AT 250 WORDS)
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