Systematic review: Vitamin D and cardiometabolic outcomes
Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J, Balk EM
Annals of internal medicine · 493 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- Office of Dietary Supplements
- Gobierno
- Public Health Agency of Canada
- Gobierno
- Public Health Agency
- Gobierno
- National Institutes of Health
- Gobierno
- Agency for Healthcare Research and Quality
- Gobierno
- U.S. Public Health Service
- Gobierno
- Health Canada
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- PHS HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK078867); U.S. Public Health Service (290 2007 10055 I); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076092); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK76092); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK79003); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK079003); National Institute of Diabetes and Digestive and Kidney Diseases (R21-DK-78867); Agency for Healthcare Research and Quality (290-2007-10055-I)
Según 11 financiadores declarados.
Publicación
- Publicado
- 2010-03-02 · Ann Intern Med · vol. 152 · número 5 · págs. 307–314
- Editorial
- American College of Physicians
- Citado
- 745 citas · más que el 100% de estudios similares · 11.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Nutritional Studies and Diet
- Palabras clave
- vitamin D, vitamin D supplementation, cardiometabolic outcomes, type 2 diabetes, hypertension, cardiovascular disease, 25-hydroxyvitamin D, blood pressure, glycemia, new-onset diabetes
- MeSH
- humans, cardiovascular diseases, hypertension, diabetes mellitus, type 2, vitamin d, risk factors, longitudinal studies, blood pressure, dietary supplements, female, male
9 autores
- Anastassios G. Pittas🇺🇸 · autor de correspondenciaTufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
- Mei Chun Chung🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
- Thomas Trikalinos🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
- Joanna Mitri🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
- Michael Brendel🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
- Kamal Patel🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
- Alice Hinda Lichtenstein🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
- Joseph Lau🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
- Ethan M. Balk🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D may modify risk for cardiometabolic outcomes (type 2 diabetes, hypertension, or cardiovascular disease).
Purpose
To examine the association between vitamin D status, including the effect of vitamin D supplementation, and cardiometabolic outcomes in generally healthy adults.
Data sources
English-language studies in MEDLINE (inception to 4 November 2009) and the Cochrane Central Register of Controlled Trials (fourth quarter of 2009).
Study selection
11 reviewers screened citations to identify longitudinal cohort studies that reported associations between vitamin D status and cardiometabolic outcomes, including randomized trials of vitamin D supplementation.
Data extraction
5 independent reviewers extracted data about study conduct, participant characteristics, outcomes, and quality. Differences were resolved by consensus.
Data synthesis
13 observational studies (14 cohorts) and 18 trials were eligible. Three of 6 analyses (from 4 different cohorts) reported a lower incident diabetes risk in the highest versus the lowest vitamin D status groups. Eight trials found no effect of vitamin D supplementation on glycemia or incident diabetes. In meta-analysis of 3 cohorts, lower 25-hydroxyvitamin D concentration was associated with incident hypertension (relative risk, 1.8 [95% CI, 1.3 to 2.4]). In meta-analyses of 10 trials, supplementation nonsignificantly reduced systolic blood pressure (weighted mean difference, -1.9 mm Hg [CI, -4.2 to 0.4 mm Hg]) and did not affect diastolic blood pressure (weighted mean difference, -0.1 mm Hg [CI, -0.7 to 0.5 mm Hg]). Lower 25-hydroxyvitamin D concentration was associated with incident cardiovascular disease in 5 of 7 analyses (6 cohorts). Four trials found no effect of supplementation on cardiovascular outcomes.
Limitations
Studies included primarily white participants. Observational studies were heterogeneous. Several trials reported post hoc analyses.
Conclusion
The association between vitamin D status and cardiometabolic outcomes is uncertain. Trials showed no clinically significant effect of vitamin D supplementation at the dosages given.
Primary funding source
National Institute of Diabetes and Digestive and Kidney Disease, the National Institutes of Health Office of Dietary Supplements, U.S. Food and Drug Administration, Agency for Healthcare Research and Quality, and Public Health Agency of Canada.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.