Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events
Wang L, Manson JE, Song Y, Sesso HD
Annals of internal medicine · 325 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL075445)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-03-02 · Ann Intern Med · vol. 152 · número 5 · págs. 315–323
- Editorial
- American College of Physicians
- Citado
- 518 citas · más que el 100% de estudios similares · 10.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, calcium supplementation, cardiovascular disease prevention, cardiovascular events, cardiovascular mortality, dialysis patients, dietary supplements
- MeSH
- humans, kidney diseases, cardiovascular diseases, calcium, dietary, vitamin d, renal dialysis, dietary supplements, female, male
4 autores
- Lu Wang🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Yiqing Song🇺🇸Brigham and Women's Hospital; Harvard University
- Howard D. Sesso🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D and calcium may affect the cardiovascular system independently and interactively.
Purpose
To assess whether vitamin D and calcium supplements reduce the risk for cardiovascular events in adults.
Data sources
Studies published in English from 1966 to July 2009 in MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials.
Study selection
Two investigators independently selected 17 prospective studies and randomized trials that examined vitamin D supplementation, calcium supplementation, or both and subsequent cardiovascular events.
Data extraction
Three investigators extracted and checked data about study designs, participants, exposures or interventions, outcomes, and data quality.
Data synthesis
Five prospective studies of patients receiving dialysis and 1 study involving a general population showed consistent reductions in cardiovascular disease (CVD) mortality among adults who received vitamin D supplements. Four prospective studies of initially healthy persons found no differences in incidence of CVD between calcium supplement recipients and nonrecipients. Results of secondary analyses in 8 randomized trials showed a slight but statistically nonsignificant reduction in CVD risk (pooled relative risk, 0.90 [95% CI, 0.77 to 1.05]) with vitamin D supplementation at moderate to high doses (approximately 1000 IU/d) but not with calcium supplementation (pooled relative risk, 1.14 [CI, 0.92 to 1.41]), or a combination of vitamin D and calcium supplementation (pooled relative risk, 1.04 [CI, 0.92 to 1.18]) compared with placebo.
Limitations
Only articles published in English that reported cardiovascular event outcomes were included. The small number of studies, the lack of trials designed specifically to assess primary effects on cardiovascular outcomes, and important between-study heterogeneity preclude definitive conclusions.
Conclusion
Evidence from limited data suggests that vitamin D supplements at moderate to high doses may reduce CVD risk, whereas calcium supplements seem to have minimal cardiovascular effects. Further research is needed to elucidate the role of these supplements in CVD prevention.
Primary funding source
The American Heart Association and the National Heart, Lung, and Blood Institute.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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