Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: the Tromsø study
Jorde R, Sneve M, Emaus N, Figenschau Y, Grimnes G
European journal of nutrition · 114 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-03-03 · Eur J Nutr · vol. 49 · número 7 · págs. 401–407
- Editorial
- Springer Science+Business Media
- Citado
- 165 citas · más que el 99% de estudios similares · 11.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 20 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Nutrition and Health Studies
- Palabras clave
- 25-hydroxyvitamin D, vitamin D status, body mass index, obesity, vitamin D supplementation, seasonal variation, dose-response relationship, Tromsø Study
- MeSH
- humans, vitamin d deficiency, obesity, vitamin d, placebos, body mass index, longitudinal studies, cross-sectional studies, adult, aged, middle aged, female, male
5 autores
- Rolf Jorde🇳🇴 · autor de correspondenciaUiT The Arctic University of Norway
- Monica Sneve🇳🇴University Hospital of North Norway
- Nina Emaus🇳🇴UiT The Arctic University of Norway
- Yngve Figenschau🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Guri Grimnes🇳🇴University Hospital of North Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The serum 25-hydroxyvitamin D (25(OH)D) levels are lower in obese than lean subjects. The present study examines the cross-sectional and longitudinal relations between body mass index (BMI) and serum 25(OH)D, and the serum 25(OH)D response to vitamin D supplementation in relation to BMI.
Methods
The Tromsø study is a longitudinal population-based multipurpose study. The fourth survey was conducted in 1994 and the sixth in 2008. The intervention study was a 1-year placebo-controlled randomized intervention trial, where the results from the 93 subjects given 40,000 IU per week are presented.
Results
A total of 10,229 subjects were included in the 2008 cross-sectional study. There was a significant negative association between serum 25(OH)D levels and BMI which was also present during the winter months. Serum 25(OH)D levels varied through seasons, but not BMI. In the longitudinal study from 1994 to 2008 which included 2,656 subjects, change in BMI was a significant negative predictor of change in 25(OH)D. In the intervention study, there was a significant and negative correlation between BMI and serum 25(OH)D both at baseline and at the end of the study. The increase in serum 25(OH)D after 1 year was significantly and inversely related to baseline BMI.
Conclusions
We have confirmed the strong association between serum 25(OH)D and BMI. The very obese need higher vitamin D doses than lean subjects to achieve the same serum 25(OH)D levels.
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