Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study
Jorde R, Sneve M, Hutchinson M, Emaus N, Figenschau Y, Grimnes G
American journal of epidemiology · 278 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universitetet i Tromsø
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-03-10 · Am J Epidemiol · vol. 171 · número 8 · págs. 903–908
- Editorial
- Oxford University Press
- Citado
- 315 citas · más que el 100% de estudios similares · 21.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Nutrition and Health Studies
- Palabras clave
- 25-hydroxyvitamin D, vitamin D status, long-term tracking, seasonal variation, body weight, vitamin D intake, physical activity, Tromsø Study, cardiovascular risk, type 2 diabetes risk, biomarker validity
- MeSH
- humans, vitamin d deficiency, cholecalciferol, vitamins, vitamin d, drug monitoring, population surveillance, nutrition assessment, analysis of variance, linear models, risk factors, chi-square distribution, epidemiologic studies, longitudinal studies, predictive value of tests, seasons, aged, middle aged, norway, female, male
6 autores
- Rolf Jorde🇳🇴 · autor de correspondenciaUiT The Arctic University of Norway
- Monica Sneve🇳🇴University Hospital of North Norway
- M. Hutchinson🇳🇴University Hospital of North Norway
- Nina Emaus🇳🇴University Hospital of North Norway
- Yngve Figenschau🇳🇴University Hospital of North Norway
- Guri Grimnes🇳🇴University Hospital of North Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Low serum 25-hydroxyvitamin D (25(OH)D) levels are associated with risk factors for cardiovascular disease, and they also appear to predict later development of type 2 diabetes, cancer, and an increased mortality rate. These predictions are all based on a single 25(OH)D measurement, but so far there are no known reports on tracking of serum 25(OH)D levels. In the present Norwegian study, serum 25(OH)D levels were measured 1) in 2,668 subjects in the 1994 and 2008 Tromsø surveys and 2) every third month for 1 year in 94 subjects randomly assigned to placebo in a vitamin D intervention study. There was a marked seasonal variation in 25(OH)D, and, depending on the method of adjusting for season, the correlation coefficient between serum 25(OH)D measurements from 1994 and 2008 ranged from 0.42 to 0.52. In the 1-year intervention study, the correlation between baseline and 12-month values was 0.80. Apart from the effect of season, changes in weight, intake of vitamin D, and physical activity were related to change in serum 25(OH)D levels. Tracking of serum 25(OH)D appears similar to that for blood pressure and serum lipids, and it provides some support for the use of a single 25(OH)D measurement to predict future health outcomes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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