Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren
Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H
The American journal of clinical nutrition · 562 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-03-10 · Am J Clin Nutr · vol. 91 · número 5 · págs. 1255–1260
- Editorial
- Elsevier BV
- Citado
- 907 citas · más que el 100% de estudios similares · 53.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Influenza Virus Research Studies · Respiratory viral infections research
- Palabras clave
- vitamin D supplementation, vitamin D3, seasonal influenza A, influenza prevention, elementary school students, asthma, winter
- MeSH
- humans, influenza a virus, body weight, cholecalciferol, placebos, body height, risk, double-blind method, patient selection, dietary supplements, adolescent, child, japan, female, male, influenza, human
6 autores
- Mitsuyoshi Urashima🇯🇵 · autor de correspondenciaJikei University School of Medicine; Kanagawa Rehabilitation Hospital; Sado General Hospital; Fuji City General Hospital
- Takaaki Segawa🇯🇵Jikei University School of Medicine; Kanagawa Rehabilitation Hospital; Sado General Hospital; Fuji City General Hospital
- M. Okazaki🇯🇵Jikei University School of Medicine; Kanagawa Rehabilitation Hospital; Sado General Hospital; Fuji City General Hospital
- Mana Kurihara🇯🇵Jikei University School of Medicine; Kanagawa Rehabilitation Hospital; Sado General Hospital; Fuji City General Hospital
- Yasuyuki Wada🇯🇵Jikei University School of Medicine; Kanagawa Rehabilitation Hospital; Sado General Hospital; Fuji City General Hospital
- Hiroyuki Ida🇯🇵Jikei University School of Medicine; Kanagawa Rehabilitation Hospital; Sado General Hospital; Fuji City General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
To our knowledge, no rigorously designed clinical trials have evaluated the relation between vitamin D and physician-diagnosed seasonal influenza.
Objective
We investigated the effect of vitamin D supplements on the incidence of seasonal influenza A in schoolchildren.
Design
From December 2008 through March 2009, we conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D(3) supplements (1200 IU/d) with placebo in schoolchildren. The primary outcome was the incidence of influenza A, diagnosed with influenza antigen testing with a nasopharyngeal swab specimen.
Results
Influenza A occurred in 18 of 167 (10.8%) children in the vitamin D(3) group compared with 31 of 167 (18.6%) children in the placebo group [relative risk (RR), 0.58; 95% CI: 0.34, 0.99; P = 0.04]. The reduction in influenza A was more prominent in children who had not been taking other vitamin D supplements (RR: 0.36; 95% CI: 0.17, 0.79; P = 0.006) and who started nursery school after age 3 y (RR: 0.36; 95% CI: 0.17, 0.78; P = 0.005). In children with a previous diagnosis of asthma, asthma attacks as a secondary outcome occurred in 2 children receiving vitamin D(3) compared with 12 children receiving placebo (RR: 0.17; 95% CI: 0.04, 0.73; P = 0.006).
Conclusion
This study suggests that vitamin D(3) supplementation during the winter may reduce the incidence of influenza A, especially in specific subgroups of schoolchildren. This trial was registered at https://center.umin.ac.jp as UMIN000001373.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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