Financiado en parte por PepsiCo, Cereal Partners Worldwide
Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention
Brownlee IA, Moore C, Chatfield M, Richardson DP, Ashby P, Kuznesof SA, Jebb SA, Seal CJ
The British journal of nutrition · 151 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- PepsiCo
- Empresa
- Cereal Partners Worldwide
- Gobierno
- Medical Research Council
Según 3 financiadores declarados.
Publicación
- Publicado
- 2010-03-23 · Br J Nutr · vol. 104 · número 1 · págs. 125–134
- Editorial
- Cambridge University Press
- Citado
- 232 citas · más que el 100% de estudios similares · 19.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Cardiovascular Health and Risk Factors
- Palabras clave
- whole grain intake, cardiovascular risk markers, refined grains, dietary intervention, body composition, plasma lipids, insulin, inflammation, coagulation, endothelial function, dietary adherence, public health recommendations
- MeSH
- endothelium, vascular, adipose tissue, humans, cardiovascular diseases, inflammation, insulin, blood glucose, lipids, body mass index, diet, models, statistical, risk factors, feeding behavior, blood coagulation, time factors, food handling, adolescent, adult, aged, middle aged, female, male, waist circumference, young adult, biomarkers, edible grain
8 autores
- Iain A. Brownlee🇬🇧Newcastle University
- Carmel S. Moore🇬🇧MRC Elsie Widdowson Laboratory
- Mark D. Chatfield🇬🇧MRC Elsie Widdowson Laboratory
- David P. Richardson
- Peter Ashby🇨🇭Cereal Partners Worldwide (Switzerland)
- Sharron A. Kuznesof🇬🇧Newcastle University
- Susan Ann Jebb🇬🇧MRC Elsie Widdowson Laboratory
- Chris J. Seal🇬🇧 · autor de correspondenciaNewcastle University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Recommendations for whole-grain (WG) intake are based on observational studies showing that higher WG consumption is associated with reduced CVD risk. No large-scale, randomised, controlled dietary intervention studies have investigated the effects on CVD risk markers of substituting WG in place of refined grains in the diets of non-WG consumers. A total of 316 participants (aged 18-65 years; BMI>25 kg/m2) consuming < 30 g WG/d were randomly assigned to three groups: control (no dietary change), intervention 1 (60 g WG/d for 16 weeks) and intervention 2 (60 g WG/d for 8 weeks followed by 120 g WG/d for 8 weeks). Markers of CVD risk, measured at 0 (baseline), 8 and 16 weeks, were: BMI, percentage body fat, waist circumference; fasting plasma lipid profile, glucose and insulin; and indicators of inflammatory, coagulation, and endothelial function. Differences between study groups were compared using a random intercepts model with time and WG intake as factors. Although reported WG intake was significantly increased among intervention groups, and demonstrated good participant compliance, there were no significant differences in any markers of CVD risk between groups. A period of 4 months may be insufficient to change the lifelong disease trajectory associated with CVD. The lack of impact of increasing WG consumption on CVD risk markers implies that public health messages may need to be clarified to consider the source of WG and/or other diet and lifestyle factors linked to the benefits of whole-grain consumption seen in observational studies.
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