Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition
Yee LD, Lester JL, Cole RM, Richardson JR, Hsu JC, Li Y, Lehman A, Belury MA, Clinton SK
The American journal of clinical nutrition · 79 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Ohio State University
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- Ohio State University (CA16058); National Center for Research Resources (M01-RR-00034); National Cancer Institute (P30 CA16058-29S1); National Cancer Institute (P-30-CA-16058); National Center for Research Resources (UL1RR025755); National Cancer Institute (CA16058); National Cancer Institute (U10 CA37447); Ohio State University (P30 CA16058); National Cancer Institute (M01-RR00034); Ohio State University (M01-RR00034); National Institutes of Health (CA‐16058); National Institutes of Health (M01-RR00034); National Institutes of Health (RR00034); National Cancer Institute (P30CA016058)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2010-03-25 · Am J Clin Nutr · vol. 91 · número 5 · págs. 1185–1194
- Editorial
- Elsevier BV
- Citado
- 97 citas · más que el 96% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Edible Oils Quality and Analysis
- Palabras clave
- omega-3 fatty acids, fish oil supplementation, breast cancer prevention, high-risk women, breast adipose tissue, fatty acid composition, docosahexaenoic acid, eicosapentaenoic acid, dose-response relationship, body mass index, serum fatty acids, dietary fat, supplement compliance, toxicity, platelet function, LDL cholesterol, alanine aminotransferase
- MeSH
- breast, adipose tissue, blood platelets, humans, breast neoplasms, hyperplasia, alanine transaminase, lipids, dietary fats, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, biopsy, body mass index, waist-hip ratio, random allocation, family, postmenopause, premenopause, dose-response relationship, drug, dietary supplements, adult, aged, middle aged, female
9 autores
- Lisa D Yee🇺🇸The Ohio State University
- Joanne L. Lester🇺🇸The Ohio State University
- Rachel M. Cole🇺🇸The Ohio State University
- Julia Richardson🇺🇸The Ohio State University
- Jason C. Hsu🇺🇸The Ohio State University
- Yan Li🇺🇸The Ohio State University
- Amy Lehman🇺🇸The Ohio State University
- Martha Ann Belury🇺🇸The Ohio State University
- Steven K. Clinton🇺🇸The Ohio State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Preclinical evidence of the preventive benefits of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) in breast cancer continues to fuel interest in the potential role of dietary fat content in reducing breast cancer risk. The dose of fish-oil/omega-3 PUFAs needed to achieve maximal target tissue effects for breast cancer prevention remains undefined.
Objective
To determine the dose effects of omega-3 fatty acids on breast adipose tissue fatty acid profiles, we conducted a study of 4 doses of omega-3 PUFAs in women at high risk of breast cancer.
Design
In this 6-mo randomized open-label study, 48 women with increased breast cancer risk received 1, 3, 6, or 9 capsules/d of an omega-3 PUFA supplement that provided 0.84, 2.52, 5.04, and 7.56 g docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) daily, respectively. Subjects made monthly visits, at which time pill counts were made and fasting blood samples were collected to determine fatty acid profiles; anthropometric measurements were made, breast adipose tissue samples were collected, and laboratory tests of toxicity (alanine aminotransferase, LDL cholesterol, and platelet function) were made at baseline and at 3 and 6 mo.
Results
All doses led to increased serum and breast adipose tissue EPA and DHA concentrations, but the response to 0.84 g DHA+EPA/d was less than the maximum possible response with > or = 2.52 g/d. Body mass index attenuated the dose response for serum tissue DHA and EPA (P = 0.015 and 0.027, respectively) and breast adipose tissue DHA (P = 0.0022) in all of the treatment groups. The incremental increase in DHA and EPA correlated inversely with baseline fat and serum values. Compliance over 6 mo was 92.9 +/- 9.2% and was unaffected by treatment arm. No severe or serious toxicities were reported.
Conclusions
Daily doses up to 7.56 g DHA+EPA were well tolerated with excellent compliance in this cohort at high risk of breast cancer. Body mass index and baseline fatty acid concentrations modulated the dose-response effects of omega-3 PUFA supplements on serum EPA and DHA and breast adipose tissue DHA.
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