A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations
McGrath JJ, Saha S, Burne TH, Eyles DW
The Journal of steroid biochemistry and molecular biology · 171 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-04-06 · J Steroid Biochem Mol Biol · vol. 121 · número 1-2 · págs. 471–477
- Editorial
- Elsevier BV
- Citado
- 240 citas · más que el 85% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 69 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Genetic Associations and Epidemiology · Nutrition, Genetics, and Disease
- Palabras clave
- 25-hydroxyvitamin D, single nucleotide polymorphisms, vitamin D binding protein, GC gene, vitamin D receptor, CYP27B1, cytochrome P450, vitamin D deficiency, serum vitamin D levels, genetic susceptibility, U-shaped dose-response relationship
- MeSH
- humans, 25-hydroxyvitamin d3 1-alpha-hydroxylase, vitamin d, vitamin d-binding protein, receptors, calcitriol, radioimmunoassay, genotype, polymorphism, single nucleotide, models, biological, models, genetic, female, male, genetic variation
4 autores
- John Joseph McGrath🇦🇺 · autor de correspondenciaThe University of Queensland; Park Centre for Mental Health; Queensland Centre for Mental Health Research
- Sukanta Saha🇦🇺Park Centre for Mental Health; Queensland Centre for Mental Health Research
- Thomas H.J. Burne🇦🇺The University of Queensland; Park Centre for Mental Health; Queensland Centre for Mental Health Research
- Darryl Walter Eyles🇦🇺The University of Queensland; Park Centre for Mental Health; Queensland Centre for Mental Health Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
In order to appreciate the association between hypovitaminosis D and various adverse health outcomes, we require a thorough understanding of how common single nucleotide polymorphisms (SNPs) influence serum concentrations of 25-hydroxyvitamin D (25OHD). We undertook a systematic review of the literature in order to identify studies that examined 25OHD concentrations, and common SNPs. We found nine studies related to the vitamin D binding protein (group-specific component, GC), and five studies examining the vitamin D receptor (VDR). SNPs in a range of cytochrome P450 enzymes have also been examined in seven studies. Replicated findings have been found between 25OHD concentrations and (a) two SNPs in GC (rs4588, rs7041), (b) one SNP in VDR (rs10735810), and (c) one SNP in CYP27B1 (rs10877012). In light of these associations, it is feasible that optimal concentrations of 25OHD required to reduce disease outcomes may vary according to genotype. We speculate that recently identified U-shaped relationships between 25OHD concentrations and disease outcomes (i.e. increased risk at both high and low concentrations) may reflect a mixture of genotype-defined subgroups. Further research is required in order to clarify the genetic architecture underlying 25OHD serum concentrations, and to unravel the mechanisms of action responsible for these associations.
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