Nut consumption and risk of stroke in US male physicians
Djoussé L, Gaziano JM, Kase CS, Kurth T
Clinical nutrition (Edinburgh, Scotland) · 27 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL-34595); National Heart, Lung, and Blood Institute (HL 26490); National Cancer Institute (CA 34944); National Cancer Institute (R01 CA034944); National Heart, Lung, and Blood Institute (R01 HL026490); National Cancer Institute (CA-097193); National Cancer Institute (R01CA097193); National Cancer Institute (CA 40360); National Heart, Lung, and Blood Institute (R01HL034595); National Cancer Institute (R01 CA040360)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-04-10 · Clin Nutr · vol. 29 · número 5 · págs. 605–609
- Editorial
- Elsevier BV
- Citado
- 36 citas · más que el 79% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Acute Ischemic Stroke Management
- Palabras clave
- nut consumption, stroke, hemorrhagic stroke, ischemic stroke, J-shaped association, dietary intake, male physicians, Physicians' Health Study, nonlinear dose-response relationship
- MeSH
- humans, nuts, coronary disease, hypertension, body mass index, risk factors, cohort studies, prospective studies, double-blind method, feeding behavior, nonlinear dynamics, adult, aged, aged, 80 and over, middle aged, physicians, united states, male, stroke, surveys and questionnaires
4 autores
- Luc Djoussé🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- J. Michael Gaziano🇺🇸Brigham and Women's Hospital
- Carlos S. Kase🇺🇸Boston University
- Tobias Kurth🇺🇸Brigham and Women's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
While nut consumption has been shown to lower the risk of hypertension and coronary disease, it is not known whether nut consumption is associated with the risk of stroke. We sought to examine whether nut consumption is associated with total and subtypes of stroke.
Methods
Prospective cohort of 21,078 participants from the Physicians' Health Study (1982-2008) who were free of stroke at baseline. Nut consumption was assessed using a simple 19-item food questionnaire and stroke cases were confirmed after reviewing medical records. We used Cox's proportional hazards regression to estimate relative risks of total, ischemic, and hemorrhagic stroke according to consumption of any nuts.
Results
During a mean follow up of 21.1 years, 1424 incident cases of stroke occurred (219 hemorrhagic, 1189 ischemic, and 16 of undetermined cause). There was no statistically significant association between nut consumption and total or ischemic stroke. In contrast, there was a suggestive non-linear relation between nut intake and hemorrhagic stroke: compared to subjects who did not consume nuts, multivariable-adjusted hazard ratios (95% CI) for hemorrhagic stroke for subjects consuming nuts <1, 1, 2-4, 5-6, and ≥7 times/week were 1.13 (0.78-1.62), 1.05 (0.70-1.58), 0.49 (0.27-0.89), 1.50 (0.79-2.84), and 1.84 (0.95-3.57), respectively (p for quadratic trend 0.12).
Conclusions
Our data showed no association between nuts and ischemic stroke and suggested a J-shaped relation between nut consumption and hemorrhagic stroke. Replication of our findings in the general population is warranted.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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