Efficacy of low-level laser therapy for body contouring and spot fat reduction
Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O, Yu Y, Greenway FL
Obesity surgery · 76 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (1P30DK072476); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-04-14 · Obes Surg · vol. 21 · número 6 · págs. 722–729
- Editorial
- Springer Science+Business Media
- Citado
- 125 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 19 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Body Contouring and Surgery · Laser Applications in Dentistry and Medicine · Dermatologic Treatments and Research
- Palabras clave
- low-level laser therapy, body contouring
- MeSH
- adipocytes, humans, triglycerides, cosmetic techniques, double-blind method, lipolysis, adolescent, adult, aged, middle aged, female, male, overweight, body fat distribution, subcutaneous fat, abdominal, lasers, semiconductor, waist circumference, young adult, low-level light therapy
8 autores
- Mary Katherine Caruso🇺🇸Louisiana State University
- Thomas S. Guillot
- Vinod K. Podichetty
- Nazar Mashtalir🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- Nikhil V. Dhurandhar🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- Olga S. Dubuisson🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- Ying Yu🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- Frank L. Greenway🇺🇸 · autor de correspondenciaPennington Biomedical Research Center; Louisiana State University System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low-level laser therapy (LLLT) is commonly used in medical applications, but scientific studies of its efficacy and the mechanism by which it causes loss of fat from fat cells for body contouring are lacking. This study examined the effectiveness and mechanism by which 635–680 nm LLLT acts as a non-invasive body contouring intervention method.
Methods
Forty healthy men and women ages 18–65 years with a BMI <30 kg/m2 were randomized 1:1 to laser or control treatment. Subject's waistlines were treated 30 min twice a week for 4 weeks. Standardized waist circumference measurements and photographs were taken before and after treatments 1, 3, and 8. Subjects were asked not to change their diet or exercise habits. In vitro assays were conducted to determine cell lysis, glycerol, and triglyceride release.
Results
Data were analyzed for those with body weight fluctuations within 1.5 kg during 4 weeks of the study. Each treatment gave a 0.4–0.5 cm loss in waist girth.Cumulative girth loss after 4 weeks was −2.15 cm (−0.78 ± 2.82 vs. 1.35 ± 2.64 cm for the control group,p < 0.05). A blinded evaluation of standardized pictures showed statistically significant cosmetic improvement after 4 weeks of laser treatment. In vitro studies suggested that laser treatment increases fat loss from adipocytes by release of triglycerides, without inducing lipolysis or cell lysis.
Conclusions
LLLT achieved safe and significant girth loss sustained over repeated treatments and cumulative over 4 weeks of eight treatments. The girth loss from the waist gave clinically and statistically significant cosmetic improvement.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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