Effects of polyunsaturated omega-3 fatty acids on responsiveness to dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: the OMEGA-PCI (OMEGA-3 fatty acids after pci to modify responsiveness to dual antiplatelet therapy) study
Gajos G, Rostoff P, Undas A, Piwowarska W
Journal of the American College of Cardiology · 79 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Department of Coronary Disease
- Gobierno
- Ministry of Science and Higher Education of Poland
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-04-01 · J Am Coll Cardiol · vol. 55 · número 16 · págs. 1671–1678
- Editorial
- Elsevier BV
- Citado
- 120 citas · más que el 99% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Antiplatelet Therapy and Cardiovascular Diseases · Fatty Acid Research and Health · Platelet Disorders and Treatments
- Palabras clave
- omega-3 polyunsaturated fatty acids, dual antiplatelet therapy, clopidogrel, aspirin, platelet response, percutaneous coronary intervention, stable coronary artery disease, platelet aggregation, VASP, aspirin resistance
- MeSH
- humans, aspirin, ticlopidine, microfilament proteins, fatty acids, omega-3, blood proteins, cell adhesion molecules, phosphoproteins, platelet aggregation inhibitors, coronary angiography, platelet count, prognosis, treatment outcome, drug therapy, combination, follow-up studies, prospective studies, double-blind method, platelet aggregation, dose-response relationship, drug, adult, aged, aged, 80 and over, middle aged, female, male, coronary artery disease, angioplasty, balloon, coronary, clopidogrel, vasodilator-stimulated phosphoprotein
4 autores
- Grzegorz Gajos🇵🇱 · autor de correspondenciaJohn Paul II Hospital
- Paweł Rostoff🇵🇱John Paul II Hospital
- Anetta Undas🇵🇱Jagiellonian University
- W Piwowarska🇵🇱Jagiellonian University; John Paul II Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
The purpose of this study was to investigate whether omega-3 polyunsaturated fatty acids (PUFAs) are able to modify platelet responsiveness to dual antiplatelet therapy in stable coronary artery disease patients undergoing percutaneous coronary intervention (PCI).
Background
Although previous studies have suggested antiplatelet properties of omega-3 polyunsaturated fatty acids, it is unknown whether they can enhance platelet inhibition on standard aspirin and clopidogrel treatment.
Methods
The OMEGA-PCI (OMEGA-3 Fatty Acids After PCI to Modify Responsiveness to Dual Antiplatelet Therapy) study was an investigator-initiated, prospective, single-center, double-blind, placebo-controlled, randomized study. Patients receiving standard dual antiplatelet therapy (aspirin 75 mg/day and clopidogrel 600 mg loading dose followed by 75 mg/day) were randomly assigned to receive the addition of 1 g of omega-3 ethyl esters (n = 33) or placebo (n = 30) for 1 month. Platelet function was measured serially by light transmission aggregometry (adenosine diphosphate and arachidonic acid [AA] were used as agonists) and assessment of the phosphorylation status of the vasodilator-stimulated phosphoprotein at baseline, 12 h, 3 to 5 days, and 30 days after randomization.
Results
The P2Y(12) reactivity index was significantly lower, by 22.2%, after 1 month of treatment with omega-3 polyunsaturated fatty acids compared with placebo when used in addition to dual antiplatelet therapy (p = 0.020). Maximal platelet aggregation induced by 5 and 20 micromol/l adenosine diphosphate was lower by 13.3% (p = 0.026) and 9.8% (p = 0.029), respectively, after 1 month of treatment with omega-3 polyunsaturated fatty acids compared with placebo. Platelet aggregation after AA stimulation was low and did not change significantly throughout the study. There were no cases of aspirin resistance during follow-up that was suggestive of good compliance with the medication.
Conclusions
The addition of omega-3 ethyl esters to the combination of aspirin and clopidogrel significantly potentiates platelet response to clopidogrel after percutaneous coronary intervention.
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