Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study
Tang L, Zirpoli GR, Jayaprakash V, Reid ME, McCann SE, Nwogu CE, Zhang Y, Ambrosone CB, Moysich KB
BMC cancer · 45 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R25CA114101)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2010-04-27 · BMC Cancer · vol. 10 · número 1 · pág. 162
- Editorial
- BioMed Central
- Citado
- 67 citas · más que el 91% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Glutathione Transferases and Polymorphisms · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Cruciferous vegetables, Medicine, Lung cancer, Case-control study, Cancer, Internal medicine, Cancer prevention, Environmental health, Physiology
- MeSH
- humans, brassicaceae, vegetables, lung neoplasms, isothiocyanates, anticarcinogenic agents, registries, logistic models, odds ratio, risk assessment, risk factors, chi-square distribution, case-control studies, feeding behavior, smoking, smoking cessation, adult, aged, aged, 80 and over, middle aged, smoking prevention
9 autores
- Li Tang🇺🇸 · autor de correspondenciaRoswell Park Comprehensive Cancer Center
- Gary Zirpoli🇺🇸Roswell Park Comprehensive Cancer Center
- Vijayvel Jayaprakash🇺🇸Roswell Park Comprehensive Cancer Center
- Mary E. Reid🇺🇸Roswell Park Comprehensive Cancer Center
- Susan E. McCann🇺🇸Roswell Park Comprehensive Cancer Center
- Chukwumere E. Nwogu🇺🇸Roswell Park Comprehensive Cancer Center
- Yuesheng Zhang🇺🇸Roswell Park Comprehensive Cancer Center
- Christine B. Ambrosone🇺🇸Roswell Park Comprehensive Cancer Center
- Kirsten B. Moysich🇺🇸Roswell Park Comprehensive Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed.
Methods
We conducted a hospital-based case-control study with lung cancer cases and controls matched on smoking status, and further adjusted for smoking status, duration, and intensity in the multivariate models. A total of 948 cases and 1743 controls were included in the analysis.
Results
Inverse linear trends were observed between intake of fruits, total vegetables, and cruciferous vegetables and risk of lung cancer (ORs ranged from 0.53-0.70, with P for trend < 0.05). Interestingly, significant associations were observed for intake of fruits and total vegetables with lung cancer among never smokers. Conversely, significant inverse associations with cruciferous vegetable intake were observed primarily among smokers, in particular former smokers, although significant interactions were not detected between smoking and intake of any food group. Of four lung cancer histological subtypes, significant inverse associations were observed primarily among patients with squamous or small cell carcinoma - the two subtypes more strongly associated with heavy smoking.
Conclusions
Our findings are consistent with the smoking-related carcinogen-modulating effect of isothiocyanates, a group of phytochemicals uniquely present in cruciferous vegetables. Our data support consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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