Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults
Biancuzzo RM, Young A, Bibuld D, Cai MH, Winter MR, Klein EK, Ameri A, Reitz R, Salameh W, Chen TC, Holick MF
The American journal of clinical nutrition · 116 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK 040561); National Center for Research Resources (M01-RR0-00533)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-04-29 · Am J Clin Nutr · vol. 91 · número 6 · págs. 1621–1626
- Editorial
- Elsevier BV
- Citado
- 185 citas · más que el 99% de estudios similares · 11.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Vitamin K Research Studies
- Palabras clave
- vitamin D2, vitamin D3, vitamin D bioavailability, vitamin D supplementation, 25-hydroxyvitamin D, vitamin D deficiency, parathyroid hormone
- MeSH
- humans, citrus sinensis, fruit, vitamin d deficiency, calcium, cholecalciferol, ergocalciferols, parathyroid hormone, double-blind method, biological availability, beverages, dietary supplements, food, fortified, adolescent, adult, aged, aged, 80 and over, middle aged, female, young adult
11 autores
- Rachael M. Biancuzzo🇺🇸Boston University; Quest Diagnostics (United States)
- Azzie Young🇺🇸Boston University; Quest Diagnostics (United States)
- Douglass Bibuld🇺🇸Boston University; Quest Diagnostics (United States)
- Mona H Cai🇺🇸Boston University; Quest Diagnostics (United States)
- Michael R Winter🇺🇸Boston University; Quest Diagnostics (United States)
- Ellen K. Klein🇺🇸Boston University; Quest Diagnostics (United States)
- Allen Ameri🇺🇸Boston University; Quest Diagnostics (United States)
- Richard E. Reitz🇺🇸Boston University; Quest Diagnostics (United States)
- Wael Antoine Salameh🇺🇸Boston University; Quest Diagnostics (United States)
- Tai C. Chen🇺🇸Boston University; Quest Diagnostics (United States)
- Michael F. Holick🇺🇸 · autor de correspondenciaBoston University; Quest Diagnostics (United States)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements.
Objectives
The objective was to compare the bioavailability of vitamin D(2) and vitamin D(3) from orange juice with that from vitamin D(2) and vitamin D(3) supplements. A secondary aim was to determine which form of vitamin D is more bioavailable in orange juice.
Design
A randomized, placebo-controlled, double-blind study was conducted in healthy adults aged 18-84 y (15-20/group) who received 1000 IU vitamin D(3), 1000 IU vitamin D(2), or placebo in orange juice or capsule for 11 wk at the end of winter.
Results
A total of 64% of subjects began the study deficient in vitamin D (ie, 25-hydroxyvitamin D [25(OH)D]) concentrations 0.1). Similarly, no significant difference in serum 25(OH)D(2) was observed between subjects who consumed vitamin D(2)-fortified orange juice and vitamin D(2) capsules (P > 0.1). No significant overall difference in parathyroid hormone concentrations was observed between the groups (P = 0.82).
Conclusion
Vitamin D(2) and vitamin D(3) are equally bioavailable in orange juice and capsules.
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