Associations between mammographic density and serum and dietary cholesterol
Tamburrini AL, Woolcott CG, Boyd NF, Yaffe MJ, Terry T, Yasui Y, Jones CA, Patten SB, Courneya KS, Friedenreich CM
Breast cancer research and treatment · 20 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-05-12 · Breast Cancer Res Treat · vol. 125 · número 1 · págs. 181–189
- Editorial
- Springer Science+Business Media
- Citado
- 31 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Digital Radiography and Breast Imaging · Cancer Risks and Factors · AI in cancer detection
- Palabras clave
- breast density, serum cholesterol, dietary cholesterol, postmenopausal women, breast cancer risk, triglycerides, alcohol consumption, lipoproteins, dense breasts
- MeSH
- humans, breast neoplasms, cholesterol, dietary, mammography, prognosis, linear models, risk assessment, risk factors, cross-sectional studies, predictive value of tests, alcohol drinking, aged, middle aged, alberta, female, adiposity, obesity, abdominal, biomarkers
10 autores
- Ame-Lia Tamburrini🇨🇦Alberta Health Services
- Christy G. Woolcott🇺🇸University of Hawaiʻi at Mānoa; University of Hawaii System
- Norman F. Boyd🇨🇦Campbell Family Institute for Breast Cancer Research
- Martin J. Yaffe🇨🇦Sunnybrook Hospital; Sunnybrook Research Institute
- Tim Terry🇨🇦Alberta Health Services; Cross Cancer Institute
- Yutaka Yasui🇨🇦Alberta Health Services; Cross Cancer Institute
- Charlotte Jones🇨🇦University of Calgary
- Scott Burton Patten🇨🇦University of Calgary
- Kerry S. Courneya🇨🇦University of Alberta
- Christine M. Friedenreich🇨🇦 · autor de correspondenciaAlberta Health Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although high mammographic density is a risk factor for postmenopausal breast cancer, its etiology remains unclear. We examined whether serum and dietary cholesterol, which increase breast cancer risk and are involved in endogenous estrogen formation, were associated with increased mammographic density. We conducted a cross-sectional analysis of 302 healthy, sedentary postmenopausal women, aged 50-74 years, enrolled in the Alberta Physical Activity and Breast Cancer Prevention Trial between 2003 and 2006. In multiple linear regression models, no significant associations were observed between serum lipids and percent density or dense tissue area (Percent density: b (change in square root percent density per unit change in cholesterol level) = -0.06 (95%CI = -0.26 to 0.13); b = 0.06 (95%CI = -0.48 to 0.61); and b = -0.11 (95%CI = -0.33 to 0.10) for total cholesterol, high-, and low-density lipoprotein, respectively; similar results found for dense area). Alcohol consumption modified the association between triglycerides and percent density (>1 drink/day: b = -0.94 (95%CI = -1.79 to -0.10); ≤ 1 drink/day: b = 0.19 (95%CI = -0.12 to 0.50); and no alcohol consumption: b = 0.15 (95%CI = -0.44 to 0.73). We found no evidence indicating any association between dietary and serum cholesterol levels and mammographic density.
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