Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder
Jazayeri S, Keshavarz SA, Tehrani-Doost M, Djalali M, Hosseini M, Amini H, Chamari M, Djazayery A
Psychiatry research · 95 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-05-14 · Psychiatry Res · vol. 178 · número 1 · págs. 112–115
- Editorial
- Elsevier BV
- Citado
- 116 citas · más que el 97% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Tryptophan and brain disorders · Treatment of Major Depression
- Palabras clave
- eicosapentaenoic acid, omega-3 fatty acids, fluoxetine, major depressive disorder, plasma cortisol, IL-1β, interleukin-6, hypothalamic-pituitary-adrenal axis, inflammatory cytokines, combination therapy, antidepressant mechanism
- MeSH
- humans, fluoxetine, hydrocortisone, eicosapentaenoic acid, antidepressive agents, interleukin-6, enzyme-linked immunosorbent assay, analysis of variance, statistics, nonparametric, adult, middle aged, female, male, interleukin-1beta, major depressive disorder
8 autores
- Shima Jazayeri🇮🇷Tehran University of Medical Sciences
- Seyed Ali Keshavarz🇮🇷Tehran University of Medical Sciences
- Mehdi Tehrani‐Doost🇮🇷 · autor de correspondenciaRoozbeh Hospital; Tehran University of Medical Sciences
- Mahmood Djalali🇮🇷Tehran University of Medical Sciences
- Mostafa Hosseini🇮🇷Tehran University of Medical Sciences
- Homayoun Amini🇮🇷Roozbeh Hospital; Tehran University of Medical Sciences
- Maryam Chamari🇮🇷Tehran University of Medical Sciences
- Abolghassem Djazayery🇮🇷Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Treatment studies have suggested that omega-3 fatty acids (omega-3 FAs) as monotherapy or adjunctive treatment have therapeutic effects in depression. The authors recently reported a study in which fluoxetine and eicosapentaenoic acid (EPA), which is an omega-3 fatty acid, appeared to be equally effective in controlling depressive symptoms and their combination was superior to either of them alone. Regulation of hypothalamus-pituitary-adrenal (HPA) axis activity and reduction of inflammatory cytokines are among several biological mechanisms which potentially explain the impact of omega-3 FAs on depression. In the present study, plasma cortisol and serum interleukin-1beta (IL-1 beta) and interleukin-6 (Il-6) were measured in patients with a diagnosis of major depressive disorder (MDD) participating in aforementioned trial to determine the effects of 8 weeks of treatment of depression with 1000 mg EPA alone or in combination with 20 mg fluoxetine on HPA axis activity and inflammatory cytokine production and compare the changes in these variables with those of treating with 20 mg fluoxetine alone. Forty-two patients were included in analysis. Two-way repeated measures analysis of variance (ANOVA) showed that plasma cortisol decreased significantly after 8 weeks of intervention without significant difference among the groups. There was no interaction between group and response to treatment over time in the cortisol response based on three-way ANOVA. Serum concentrations of IL-1beta and IL-6 did not change significantly after intervention. In conclusion, EPA alone or in combination with fluoxetine, as well as fluoxetine alone decreased serum cortisol after 8 weeks of treatment in patients with major depression disorder (MDD) without any significant effect of response to treatment. Serum IL-1beta and IL-6 did not change significantly after intervention. These findings suggest that EPA may exert its therapeutic effects through reduction of cortisol.
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