Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans
Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM
Journal of applied physiology (Bethesda, Md. : 1985) · 445 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-05-13 · J Appl Physiol (1985) · vol. 109 · número 1 · págs. 135–148
- Editorial
- American Physiological Society
- Citado
- 603 citas · más que el 100% de estudios similares · 95.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 83 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Muscle metabolism and nutrition · Nitric Oxide and Endothelin Effects
- Palabras clave
- Phosphocreatine, Nitrite, Dietary Nitrate, Chemistry, Animal science, Internal medicine, Crossover study, Nitrate, Endocrinology, Placebo, Medicine, Energy metabolism, Biology
- MeSH
- knee, muscle, skeletal, humans, beta vulgaris, nitrates, nitrites, phosphocreatine, pulmonary ventilation, exercise, oxygen consumption, muscle contraction, beverages, dietary supplements, adult, male, muscle strength, young adult
9 autores
- Stephen J. Bailey🇬🇧University of Exeter; Heavitree Hospital
- Jonathan Fulford🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- Anni Vanhatalo
- Paul Graham Winyard🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- Jamie R. Blackwell
- Fred J. DiMenna
- Daryl Paul Wilkerson
- Nigel Benjamin🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- ANDREW MARK JONES · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of this study was to elucidate the mechanistic bases for the reported reduction in the O(2) cost of exercise following short-term dietary nitrate (NO(3)(-)) supplementation. In a randomized, double-blind, crossover study, seven men (aged 19-38 yr) consumed 500 ml/day of either nitrate-rich beet root juice (BR, 5.1 mmol of NO(3)(-)/day) or placebo (PL, with negligible nitrate content) for 6 consecutive days, and completed a series of low-intensity and high-intensity "step" exercise tests on the last 3 days for the determination of the muscle metabolic (using (31)P-MRS) and pulmonary oxygen uptake (Vo(2)) responses to exercise. On days 4-6, BR resulted in a significant increase in plasma [nitrite] (mean +/- SE, PL 231 +/- 76 vs. BR 547 +/- 55 nM; P < 0.05). During low-intensity exercise, BR attenuated the reduction in muscle phosphocreatine concentration ([PCr]; PL 8.1 +/- 1.2 vs. BR 5.2 +/- 0.8 mM; P < 0.05) and the increase in Vo(2) (PL 484 +/- 41 vs. BR 362 +/- 30 ml/min; P < 0.05). During high-intensity exercise, BR reduced the amplitudes of the [PCr] (PL 3.9 +/- 1.1 vs. BR 1.6 +/- 0.7 mM; P < 0.05) and Vo(2) (PL 209 +/- 30 vs. BR 100 +/- 26 ml/min; P < 0.05) slow components and improved time to exhaustion (PL 586 +/- 80 vs. BR 734 +/- 109 s; P < 0.01). The total ATP turnover rate was estimated to be less for both low-intensity (PL 296 +/- 58 vs. BR 192 +/- 38 microM/s; P < 0.05) and high-intensity (PL 607 +/- 65 vs. BR 436 +/- 43 microM/s; P < 0.05) exercise. Thus the reduced O(2) cost of exercise following dietary NO(3)(-) supplementation appears to be due to a reduced ATP cost of muscle force production. The reduced muscle metabolic perturbation with NO(3)(-) supplementation allowed high-intensity exercise to be tolerated for a greater period of time.
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