Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery
Jiang ZM, Wilmore DW, Wang XR, Wei JM, Zhang ZT, Gu ZY, Wang S, Han SM, Jiang H, Yu K
The British journal of surgery · 60 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Health and Family Planning Commission of the People's Republic of China
- Gobierno
- Chinese Ministry of Health
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-04-22 · Br J Surg · vol. 97 · número 6 · págs. 804–809
- Editorial
- Oxford University Press
- Citado
- 80 citas · más que el 95% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Enhanced Recovery After Surgery · Fatty Acid Research and Health
- Palabras clave
- Medicine, Interquartile range, Fish oil, Randomized controlled trial, Parenteral nutrition, Soybean oil, Surgery, Adverse effect, Gastrointestinal cancer, Clinical trial, Incidence (geometry), Systemic inflammatory response syndrome, Gastrointestinal function, Gastroenterology, Anesthesia, Internal medicine, Cancer, Colorectal cancer, Fish <Actinopterygii>, Sepsis
- MeSH
- humans, respiratory tract infections, urinary tract infections, surgical wound infection, gastrointestinal neoplasms, colonic neoplasms, postoperative complications, body weight, soybean oil, fish oils, tumor necrosis factor-alpha, interleukin-6, emulsions, body mass index, cd4-cd8 ratio, length of stay, postoperative care, infusions, intravenous, analysis of variance, aged, middle aged, cost-benefit analysis, female, male
10 autores
- Zhu Jiang🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College
- Douglas W. Wilmore🇺🇸Brigham and Women's Hospital; Harvard University
- Xun Wang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Jinqi Wei🇨🇳Beijing Hospital
- Z T Zhang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Zixiao Gu
- Shu Wang🇨🇳Peking University; Peking University People's Hospital
- Shaojie Han🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Hong Jiang🇨🇳Sichuan Provincial Hospital of Traditional Chinese Medicine
- Kang Yu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Specific immunonutrients may reduce the incidence of postoperative complications and shorten recovery time. This randomized trial evaluated the clinical efficacy of a fish oil emulsion on outcome and immune function after gastrointestinal cancer surgery.
Methods
A total of 206 patients with gastrointestinal or colonic cancer were randomized to receive isocaloric and isonitrogenous intravenous infusions of either soybean oil alone (1.2 g per kg bodyweight per day; control group, 103 analysed) or soybean plus fish oil emulsion (1.0 and 0.2 g per kg per day respectively; treatment group, 100 analysed) over 20-24 h daily for 7 days after surgery.
Results
Baseline data were comparable in the two groups. There were fewer infectious complications (four versus 12 on day 8; P = 0.066), systemic inflammatory response syndrome (SIRS) was significantly less common (four versus 13; P = 0.039) and hospital stay was significantly shorter (mean(s.d.) 15(5) versus 17(8) days; P = 0.041) in the treatment group. Total postoperative medical costs were comparable in the two groups (mean(s.d.) US $ 1269(254) and 1302(324) in treatment and control groups respectively; P = 0.424). The median (interquartile range) difference in CD4/CD8 between days 1 and 8 after surgery was + 0.30 (0.06 to 0.79) in patients receiving fish oil and + 0.20 (-0.19 to 0.55) in controls (P = 0.021). No severe adverse events occurred in either group.
Conclusion
Fish oil emulsion-supplemented parenteral nutrition significantly reduced SIRS and length of hospital stay. These clinical benefits may be related to normalization of cellular immune functions and modulation of the inflammatory response.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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