Creatine supplementation for patients with COPD receiving pulmonary rehabilitation: a systematic review and meta-analysis
Al-Ghimlas F, Todd DC
Respirology (Carlton, Vic.) · 27 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Japan Agency for Medical Research and Development
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-05-24 · Respirology · vol. 15 · número 5 · págs. 785–795
- Editorial
- Wiley
- Citado
- 38 citas · más que el 49% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- De pago
- Áreas de investigación
- Chronic Obstructive Pulmonary Disease (COPD) Research · Muscle metabolism and nutrition · Nutrition and Health in Aging
- Palabras clave
- creatine supplementation, chronic obstructive pulmonary disease, pulmonary rehabilitation, exercise capacity, muscle strength, health-related quality of life, neuromuscular disorders, heart failure
- MeSH
- muscle, skeletal, humans, pulmonary disease, chronic obstructive, creatine, treatment outcome, exercise tolerance, quality of life, dietary supplements, muscle strength, randomized controlled trials as topic
2 autores
- Fahad Al-Ghimlas🇰🇼 · autor de correspondenciaAmiri Hospital
- David C. TODD🇨🇦St. Joseph’s Healthcare Hamilton; McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objective
Creatine improves muscle strength in exercising healthy individuals, and in patients with neuromuscular disease and heart failure. The aim of this study was to assess whether creatine supplementation improves pulmonary rehabilitation (PR) outcomes in patients with COPD.
Methods
A systematic review and meta-analysis was performed of randomized controlled trials published between January 1966 and February 2009 that evaluated the effect of creatine compared with placebo on exercise capacity, muscle strength and health-related quality of life (HR-QoL) in patients undergoing PR for COPD. The pooled estimates were expressed as mean differences (MD) or standardized mean differences (SMD).
Results
Four randomized controlled trials that included 151 patients were identified. There was no effect of creatine supplementation on exercise capacity (SMD -0.01, 95% CI: -0.42 to 0.22, n = 151). Creatine supplementation did not improve lower extremity muscle strength (SMD 0.03, 95% CI: -0.55 to 0.61, n = 140) or upper limb muscular strength (SMD 0.02, 95% CI: -0.33 to 0.38, n = 128) compared with placebo. Two studies (n = 48) assessed quality of life using the St. George's Respiratory Disease Questionnaire. There were no differences in HR-QoL according to domain or total scores. Overall, creatine appeared to be safe and was well tolerated. Quality assessment of the studies showed important limitations.
Conclusions
Creatine supplementation does not improve exercise capacity, muscle strength or HR-QoL in patients with COPD receiving PR. However, important limitations were identified in the quality of the available evidence, suggesting that further research is required in this area.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.