Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption
Rogers PJ, Hohoff C, Heatherley SV, Mullings EL, Maxfield PJ, Evershed RP, Deckert J, Nutt DJ
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 141 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Subvenciones
- Biotechnology and Biological Sciences Research Council (BBS/B/01855)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-06-02 · Neuropsychopharmacology · vol. 35 · número 9 · págs. 1973–1983
- Editorial
- Springer Nature
- Citado
- 212 citas · más que el 99% de estudios similares · 11.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Neurotransmitter Receptor Influence on Behavior · Genetic Associations and Epidemiology
- Palabras clave
- caffeine, anxiogenic effects, alertness, adenosine A2A receptor, adenosine A1 receptor, adenosine receptors, single nucleotide polymorphisms, caffeine tolerance, headache, coffee consumption, genetic susceptibility
- MeSH
- saliva, humans, headache, substance withdrawal syndrome, xanthines, caffeine, receptor, adenosine a1, receptor, adenosine a2a, central nervous system stimulants, double-blind method, anxiety, psychomotor performance, arousal, reaction time, dose-response relationship, drug, genotype, linkage disequilibrium, polymorphism, genetic, adult, middle aged, female, male, young adult
8 autores
- Peter J. Rogers🇬🇧 · autor de correspondenciaUniversity of Bristol
- Christa Hohoff🇩🇪University of Münster
- Susan V. Heatherley🇬🇧University of Bristol
- Emma L. Mullings🇬🇧University of Bristol
- Peter J Maxfield🇬🇧University of Bristol
- Richard P. Evershed🇬🇧University of Bristol
- Jürgen Deckert🇩🇪University of Würzburg
- David Nutt🇬🇧Hammersmith Hospital; Imperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine, a widely consumed adenosine A(1) and A(2A) receptor antagonist, is valued as a psychostimulant, but it is also anxiogenic. An association between a variant within the ADORA2A gene (rs5751876) and caffeine-induced anxiety has been reported for individuals who habitually consume little caffeine. This study investigated whether this single nucleotide polymorphism (SNP) might also affect habitual caffeine intake, and whether habitual intake might moderate the anxiogenic effect of caffeine. Participants were 162 non-/low (NL) and 217 medium/high (MH) caffeine consumers. In a randomized, double-blind, parallel groups design they rated anxiety, alertness, and headache before and after 100 mg caffeine and again after another 150 mg caffeine given 90 min later, or after placebo on both occasions. Caffeine intake was prohibited for 16 h before the first dose of caffeine/placebo. Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype. Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache. Placebo administration in MH participants decreased alertness and increased headache. Caffeine did not increase alertness in NL participants. With frequent consumption, substantial tolerance develops to the anxiogenic effect of caffeine, even in genetically susceptible individuals, but no net benefit for alertness is gained, as caffeine abstinence reduces alertness and consumption merely returns it to baseline.
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