Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study
Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, Weiss ST, Litonjua AA, Childhood Asthma Management Program Research Group
The Journal of allergy and clinical immunology · 319 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (U01 HL 51510); National Heart, Lung, and Blood Institute (N01-HR-16045); National Heart, Lung, and Blood Institute (U01 HL 51843); National Center for Research Resources (M01RR02719-14); National Heart, Lung, and Blood Institute (T32 HL07427); National Center for Research Resources (M01RR-00051); National Heart, Lung, and Blood Institute (U01 HL 51831); National Heart, Lung, and Blood Institute (T32HL007427); National Heart, Lung, and Blood Institute (U01HL075419); National Heart, Lung, and Blood Institute (N01-HR-16051); National Heart, Lung, and Blood Institute (U01-HL065899); National Center for Research Resources (M01RR003186); National Center for Research Resources (M01-RR000079); National Heart, Lung, and Blood Institute (R21HL089842); National Heart, Lung, and Blood Institute (U10 HL051831); National Heart, Lung, and Blood Institute (N01-HR16048); National Heart, Lung, and Blood Institute (N01-HR-16046); National Heart, Lung, and Blood Institute (N01HR16047); National Heart, Lung, and Blood Institute (U10 HL051845); National Heart, Lung, and Blood Institute (U01 HL51845); National Heart, Lung, and Blood Institute (U01HL51834); National Heart, Lung, and Blood Institute (N01-HR16044); National Center for Research Resources (M01 RR-00079); National Heart, Lung, and Blood Institute (U10 HL051834); National Heart, Lung, and Blood Institute (N01HR16049); National Heart, Lung, and Blood Institute (R01HL086601); National Heart, Lung, and Blood Institute (P01HL083069); National Heart, Lung, and Blood Institute (U01 HL65899); National Center for Research Resources (M01 RR0099718-24); National Heart, Lung, and Blood Institute (N01HR16052); National Heart, Lung, and Blood Institute (N01-HR16050); National Heart, Lung, and Blood Institute (U10 HL051843); National Center for Research Resources (RR.00036); National Center for Research Resources (M01 RR-03186)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-06-11 · J Allergy Clin Immunol · vol. 126 · número 1 · págs. 52–58.e5
- Editorial
- Elsevier BV
- Citado
- 509 citas · más que el 100% de estudios similares · 30.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Asthma and respiratory diseases · Dermatology and Skin Diseases
- Palabras clave
- vitamin D insufficiency, asthma exacerbations, 25-hydroxyvitamin D, childhood asthma, persistent asthma, hospitalization, emergency department visits, racial differences, African American children, Childhood Asthma Management Program, budesonide, nedocromil
- MeSH
- humans, asthma, bronchial hyperreactivity, adrenal cortex hormones, vitamin d, forced expiratory volume, double-blind method, child, female, male
8 autores
- John M. Brehm🇺🇸Brigham and Women's Hospital; Harvard University
- Brooke Schuemann🇺🇸Brigham and Women's Hospital
- Anne L. Fuhlbrigge🇺🇸Brigham and Women's Hospital
- Bruce W. Hollis🇺🇸Medical University of South Carolina
- Robert C. Strunk🇺🇸St. Louis Children's Hospital; Washington University in St. Louis
- Robert S. Zeiger🇺🇸Kaiser Permanente; Kaiser Permanente San Diego Medical Center
- Scott T. Weiss🇺🇸Brigham and Women's Hospital; Harvard University
- Augusto A. Litonjua🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Asthma exacerbations, most often caused by respiratory tract infections, are the leading causes of asthma morbidity and comprise a significant proportion of asthma-related costs. Vitamin D status might play a role in preventing asthma exacerbations.
Objectives
We sought to assess the relationship between serum vitamin D levels and subsequent severe asthma exacerbations.
Methods
We measured 25-hydroxyvitamin D levels in sera collected from 1024 children with mild-to-moderate persistent asthma at the time of enrollment in a multicenter clinical trial of children randomized to receive budesonide, nedocromil, or placebo (as-needed beta-agonists): the Childhood Asthma Management Program. Using multivariable modeling, we examined the relationship between baseline vitamin D levels and the odds of any hospitalization or emergency department visit over the 4 years of the trial.
Results
Thirty-five percent of all subjects were vitamin D insufficient, as defined by a level of 30 ng/mL or less 25-hydroxyvitamin D. Mean vitamin D levels were lowest in African American subjects and highest in white subjects. After adjusting for age, sex, body mass index, income, and treatment group, insufficient vitamin D status was associated with a higher odds of any hospitalization or emergency department visit (odds ratio, 1.5; 95% CI, 1.1-1.9; P = .01).
Conclusion
Vitamin D insufficiency is common in this population of North American children with mild-to-moderate persistent asthma and is associated with higher odds of severe exacerbation over a 4-year period.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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