Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability
Cawood AL, Ding R, Napper FL, Young RH, Williams JA, Ward MJ, Gudmundsen O, Vige R, Payne SP, Ye S, Shearman CP, Gallagher PJ, Grimble RF, Calder PC
Atherosclerosis · 172 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- British Heart Foundation
- Universidad u hospital
- University of Southampton
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-05-21 · Atherosclerosis · vol. 212 · número 1 · págs. 252–259
- Editorial
- Elsevier BV
- Citado
- 243 citas · más que el 99% de estudios similares · 15.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Atherosclerosis and Cardiovascular Diseases · Cerebrovascular and Carotid Artery Diseases
- Palabras clave
- eicosapentaenoic acid, omega-3 fatty acids, atherosclerotic plaque, plaque stability, plaque inflammation, carotid endarterectomy, foam cells, T cells, matrix metalloproteinases, interleukin-6, ICAM-1, dietary supplementation
- MeSH
- t-lymphocytes, foam cells, humans, carotid artery diseases, rupture, spontaneous, inflammation, matrix metalloproteinases, docosahexaenoic acids, eicosapentaenoic acid, phospholipids, rna, messenger, inflammation mediators, cytokines, capsules, drug combinations, treatment outcome, preoperative care, endarterectomy, carotid, administration, oral, chi-square distribution, double-blind method, gene expression regulation, dietary supplements, adult, aged, aged, 80 and over, middle aged, england, female, male
14 autores
- Abbie L. Cawood🇬🇧University of Southampton
- Ren Ding🇬🇧University of Southampton
- Frances L. Napper🇬🇧University of Southampton
- Ruth H. Young🇬🇧University of Southampton
- Jennifer A. Williams🇬🇧University of Southampton
- Matthew J. Ward🇬🇧University of Southampton
- Ola Gudmundsen
- Runar Vige
- Simon P.K. Payne🇬🇧Queen Alexandra Hospital
- Shu Ye🇬🇧University of Southampton
- Ciff P. Shearman🇬🇧University of Southampton
- Patrick J. Gallagher🇬🇧University of Southampton
- Robert F. Grimble🇬🇧University of Southampton
- Philip C. Calder🇬🇧 · autor de correspondenciaUniversity of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine n-3 polyunsaturated fatty acid (PUFA) incorporation into atherosclerotic plaques and the association with plaque inflammation and stability.
Methods and results
Patients awaiting carotid endarterectomy (n=121) were randomised to consume control capsules or n-3 PUFA ethyl ester capsules until surgery (median 21 days). The fatty acid compositions of plasma and carotid plaque phospholipids, plaque features, and expression of inflammatory genes were determined. The proportion of eicosapentaenoic acid (EPA) was higher (P<0.0001) in carotid plaque phospholipids in patients in the n-3 PUFA group. Plaques from patients in the n-3 PUFA group had fewer foam cells (P=0.0390). There were no other differences between plaques in the two groups with regard to histological characteristics or morphology. Plaque stability was not different between the two groups. However, the EPA content of plaque phospholipids was inversely associated with plaque instability (P=0.0209), plaque inflammation (P=0.0108), the number of T cells in the plaque (P=0.0097) and a summary score considering a range of plaque features (P=0.0425). Plaques from patients who received n-3 PUFAs had significantly lower levels of mRNA for matrix metalloproteinases (MMP)-7 (P=0.0055), -9 (P=0.0048) and -12 (P=0.0044) and for interleukin-6 (P=0.0395) and intercellular adhesion molecule 1 (P=0.0142).
Conclusions
Atherosclerotic plaques readily incorporate EPA. A higher plaque EPA content is associated with a reduced number of foam cells and T cells, less inflammation and increased stability.
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