Intake of cruciferous vegetables modifies bladder cancer survival
Tang L, Zirpoli GR, Guru K, Moysich KB, Zhang Y, Ambrosone CB, McCann SE
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 93 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R25CA114101)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-07-01 · Cancer Epidemiol Biomarkers Prev · vol. 19 · número 7 · págs. 1806–1811
- Editorial
- American Association for Cancer Research
- Citado
- 124 citas · más que el 94% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Sulfur Compounds in Biology · Phytochemicals and Antioxidant Activities
- Palabras clave
- Cruciferous vegetables, Medicine, Bladder cancer, Hazard ratio, Cancer, Proportional hazards model, Cancer registry, Internal medicine, Confidence interval
- MeSH
- humans, brassica, vegetables, isothiocyanates, prognosis, diet, seer program, risk factors, survival analysis, prospective studies, aged, aged, 80 and over, middle aged, united states, female, male, urinary bladder neoplasms, surveys and questionnaires
7 autores
- Li Tang🇺🇸 · autor de correspondenciaRoswell Park Comprehensive Cancer Center
- Gary Zirpoli🇺🇸Roswell Park Comprehensive Cancer Center
- Khurshid A. Guru🇺🇸Roswell Park Comprehensive Cancer Center
- Kirsten B. Moysich🇺🇸Roswell Park Comprehensive Cancer Center
- Yuesheng Zhang🇺🇸Roswell Park Comprehensive Cancer Center
- Christine B. Ambrosone🇺🇸Roswell Park Comprehensive Cancer Center
- Susan E. McCann🇺🇸Roswell Park Comprehensive Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intake of cruciferous vegetables, a rich source of dietary isothiocyanates, has been inversely associated with risk of bladder cancer. Due to the potent antiproliferative effects of dietary isothiocyanates on bladder cancer in in vitro and in vivo models, cruciferous vegetable intake may also play a role in survival among patients with bladder cancer.
Methods
Using information obtained from the Roswell Park Cancer Institute Tumor Registry, patient medical records, and routinely collected questionnaire data, we examined potential associations between intake of cruciferous vegetables and survival among bladder cancer patients. As cooking can substantially reduce or destroy isothiocyanates, consumption of raw versus cooked cruciferous vegetables was examined separately. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazard models.
Results
A total of 239 bladder cancer patients were included in the study. After an average of 8 years of follow-up, 179 deaths occurred, with 101 deaths attributable to bladder cancer. After adjustment for other prognostic factors, a strong and significant inverse association was observed between bladder cancer mortality and broccoli intake, in particular raw broccoli intake (> or =1 versus <1 serving per month; HR for overall death, 0.57; 95% CI, 0.39-0.83; HR for disease-specific death, 0.43; 95% CI, 0.25-0.74). There were no significant associations for total vegetables, total fruits, or other individual cruciferous vegetables.
Conclusions
Considering the strong preclinical evidence, intake of broccoli may improve bladder cancer survival.
Impact
Further prospective investigation is warranted to confirm the potential role of cruciferous vegetables in bladder cancer prognosis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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