Calcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative
Manson JE, Allison MA, Carr JJ, Langer RD, Cochrane BB, Hendrix SL, Hsia J, Hunt JR, Lewis CE, Margolis KL, Robinson JG, Rodabough RJ, Thomas AM, Women's Health Initiative and Women's Health Initiative-Coronary Artery Calcium Study Investigators
Menopause (New York, N.Y.) · 91 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- WHI NIH HHS
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institutes of Health (N01 WH 44221); National Institutes of Health (N01-WH-3-2115); National Institutes of Health (N01WH24152); National Institutes of Health (N01-WH-3-2122); National Institutes of Health (N01WH42129-32); National Institutes of Health (N01-WH-32108-9); National Institutes of Health (N01WH 32111-13); National Institutes of Health (N01 WH 32105-6); National Institutes of Health (N01 WH022110); National Institutes of Health (N01-WH-32100-2); National Institutes of Health (N01-WH-42107-26); National Institutes of Health (N01WH 32118-32119); National Institutes of Health (N01 WH032109); National Institute on Aging (P30AG028740)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-06-15 · Menopause · vol. 17 · número 4 · págs. 683–691
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 128 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Cardiac Imaging and Diagnostics · Bone health and osteoporosis research
- Palabras clave
- calcium supplementation, vitamin D3 supplementation, coronary artery calcification, atherosclerotic plaque burden, postmenopausal women, Women's Health Initiative, estrogen therapy, calcium carbonate, coronary risk factors, cardiovascular risk
- MeSH
- humans, calcinosis, calcium carbonate, cholecalciferol, tomography, x-ray computed, coronary angiography, double-blind method, postmenopause, middle aged, female, bone density conservation agents, coronary artery disease
13 autores
- JoAnn E. Manson🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- Matthew Allison🇺🇸University of California San Diego
- J. Jeffrey Carr🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Robert D. Langer
- Barbara B. Cochrane🇺🇸University of Washington
- Susan L. Hendrix🇺🇸Detroit Medical Center; Hutzel Women's Hospital
- Judith A. Hsia🇺🇸George Washington University
- Julie R. Hunt🇺🇸Fred Hutch Cancer Center
- Cora Elizabeth Lewis🇺🇸University of Alabama at Birmingham
- Karen L. Margolis🇺🇸Brigham and Women's Hospital; University of Minnesota; Harvard University
- Jennifer G. Robinson🇺🇸University of Iowa; Brigham and Women's Hospital; Harvard University
- Rebecca J. Rodabough🇺🇸Fred Hutch Cancer Center
- Asha M. Thomas🇺🇸Brigham and Women's Hospital; Harvard University; University of California San Diego
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Coronary artery calcified plaque is a marker for atheromatous plaque burden and predicts future risk of cardiovascular events. The relationship between calcium plus vitamin D (calcium/D) supplementation and coronary artery calcium (CAC) has not been previously assessed in a randomized trial setting. We compared CAC scores after trial completion between women randomized to calcium/vitamin D supplementation and women randomized to placebo.
Methods
In an ancillary substudy of women randomized to calcium carbonate (1,000 mg of elemental calcium daily) plus vitamin D3 (400 IU daily) or placebo, nested within the Women's Health Initiative trial of estrogen among women who underwent hysterectomy, we measured CAC with cardiac CT in 754 women aged 50 to 59 years at randomization. Imaging for CAC was performed at 28 of 40 centers after a mean of 7 years of treatment, and scans were read centrally. CAC scores were measured by a central reading center with masking to randomization assignments.
Results
Posttrial CAC measurements were similar in women randomized to calcium/D supplementation and those receiving placebo. The mean CAC score was 91.6 for women receiving calcium/D and 100.5 for women receiving placebo (rank test P value = 0.74). After adjustment for coronary risk factors, multivariate odds ratios for increasing CAC score cutpoints (CAC >0, > or =10, and > or =100) for calcium/D versus placebo were 0.92 (95% CI, 0.64-1.34), 1.29 (0.88-1.87), and 0.90 (0.56-1.44), respectively. Corresponding odds ratios among women with a 50% or higher adherence to study pills and for higher levels of CAC (>300) were similar.
Conclusions
Treatment with moderate doses of calcium plus vitamin D3 did not seem to alter coronary artery calcified plaque burden among postmenopausal women. Whether higher or lower doses would affect this outcome remains uncertain.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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