A double-blind, randomized clinical trial of the effect of omega-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition
Skouroliakou M, Konstantinou D, Koutri K, Kakavelaki C, Stathopoulou M, Antoniadi M, Xemelidis N, Kona V, Markantonis S
European journal of clinical nutrition · 92 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-06-16 · Eur J Clin Nutr · vol. 64 · número 9 · págs. 940–947
- Editorial
- Springer Nature
- Citado
- 128 citas · más que el 98% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Infant Nutrition and Health
- Palabras clave
- omega-3 fatty acids, preterm infants, parenteral nutrition, lipid emulsions, SMOFlipid, Intralipid, oxidative stress, antioxidant capacity, vitamin E, vitamin A
- MeSH
- humans, vitamin a, vitamin e, fatty acids, omega-3, fat emulsions, intravenous, antioxidants, treatment outcome, parenteral nutrition, length of stay, double-blind method, oxidation-reduction, oxidative stress, infant, newborn, infant, premature, greece, female, male, infant nutritional physiological phenomena
9 autores
- Maria Skouroliakou🇬🇷 · autor de correspondenciaHarokopio University of Athens
- D Konstantinou
- Katerina Koutri
- Christina Kakavelaki🇬🇷Harokopio University of Athens
- Maria G. Stathopoulou🇬🇷Harokopio University of Athens
- Marita Antoniadi
- N Xemelidis🇬🇷National and Kapodistrian University of Athens
- V Kona🇬🇷Harokopio University of Athens
- S Markantonis🇬🇷National and Kapodistrian University of Athens
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
The aim of this study was to research and draw conclusions about the effect of a parenteral nutrition (PN) fat emulsion, rich in omega-3 fatty acids, on the antioxidant markers of preterm infants, when compared with a standard fat emulsion. This was a double-blind, parallel-group study conducted in Athens, Greece, using an equal randomization method.
Subjects/methods
Thirty-eight infants were selected using a double-blind method and a computer-generated randomization list. Both groups received PN, based on the same protocols. Group A received SMOFlipid fat emulsion, while group B received the standard fat emulsion (Intralipid). Serum levels of vitamin A, E and total antioxidant potential (TAP) were measured on days 0, 7 and 14 of PN support. Clinical and biochemical data were collected on days 0, 14 and on the day of discharge.
Results
Serum levels of vitamin E and A were significantly increased in group A, while only vitamin A serum level was increased in group B on the fourteenth day (group A: vitamin E: P-value=0.002, vitamin A: P-value=0.000, group B: vitamin E: P-value=0.065, vitamin A: P-value=0.000). TAP was increased only in the intervention group (group A: P-value=0.000, group B: P-value=0.287). Mild anemia was developed in both groups, while no differences were detected in the infection rate, days of hospitalization, days of ventilator support and days of phototherapy.
Conclusions
Oxidative stress was significantly reduced in those neonates fed with omega-3 fatty acids, whereas no effect was observed in the neonates fed with standard lipids. Intervention had no effect on infants' growth and clinical outcome.
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