Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines
Faria A, Pestana D, Teixeira D, de Freitas V, Mateus N, Calhau C
Phytotherapy research : PTR · 67 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-06-17 · Phytother Res · vol. 24 · número 12 · págs. 1862–1869
- Editorial
- Wiley
- Citado
- 147 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Hops Chemistry and Applications · Plant Gene Expression Analysis
- Palabras clave
- Anthocyanin, Pyruvic acid, Chemistry, Biochemistry, Apoptosis, Cell growth, Cell culture, Biology, Food science
- MeSH
- cell line, tumor, humans, fruit, breast neoplasms, pyruvic acid, anthocyanins, plant extracts, antineoplastic agents, phytogenic, cell proliferation, cell survival, caspase 3, blueberry plants
6 autores
- Ana Faria🇵🇹 · autor de correspondenciaUniversidade do Porto
- Diogo Pestana🇵🇹Universidade do Porto
- Diana Teixeira🇵🇹Universidade do Porto
- Victor Armando Pereira de Freitas🇵🇹Universidade do Porto
- Nuno Filipe da Cruz Batista Mateus🇵🇹Universidade do Porto
- Conceição Calhau🇵🇹Universidade do Porto
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of this study was to investigate the anticancer properties of an anthocyanin-pyruvic acid adduct extract, which is being developed aiming to be further applied in the food industry. An anthocyanin extract from blueberry (extract I) and an anthocyanin-pyruvic acid adduct extract (extract II) were tested on two breast cancer cell lines (MDA-MB-231 and MCF7). Proliferation was assessed by SRB assay and ³H-thymidine incorporation. Caspase-3 activity was determined in the presence of both extracts. Their capacity as chemoattractants and their invasive potential were also assayed. In both cell lines, extracts I and II significantly reduced cell proliferation at 250 μg/mL, after 24 h of cell incubation. Caspase-3 activity was not altered by the extracts (250 μg/mL) in either cell line, with the exception of extract II in MCF-7, which increased its activity, probably explaining its effects on cell proliferation. Both extracts (250 μg/mL) demonstrated significant antiinvasive potential in both cell lines. Furthermore, they did not demonstrate any capacity for chemotaxis. In conclusion, blueberry anthocyanins and the respective anthocyanin-pyruvic acid adducts demonstrated anticancer properties by inhibiting cancer cell proliferation and by acting as cell antiinvasive factors and chemoinhibitors. The anthocyanin-pyruvic acid adduct extract showed a more pronounced effect in MDA-MB-231, suggesting an effect independent of estrogen receptors.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.