Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin
El-Sharkawy H, Aboelsaad N, Eliwa M, Darweesh M, Alshahat M, Kantarci A, Hasturk H, Van Dyke TE
Journal of periodontology · 140 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Mansoura University
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-06-23 · J Periodontol · vol. 81 · número 11 · págs. 1635–1643
- Editorial
- Wiley
- Citado
- 203 citas · más que el 99% de estudios similares · 11.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral microbiology and periodontitis research · Fatty Acid Research and Health · Periodontal Regeneration and Treatments
- Palabras clave
- chronic periodontitis, omega-3 fatty acids, dietary supplementation, fish oil, low-dose aspirin, scaling and root planing, adjunctive periodontal therapy, RANKL, matrix metalloproteinase-8, probing depth, attachment gain, anti-inflammatory therapy
- MeSH
- saliva, humans, gingival hemorrhage, periodontal attachment loss, periodontal pocket, aspirin, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, anti-inflammatory agents, non-steroidal, anti-inflammatory agents, placebos, treatment outcome, combined modality therapy, dental plaque index, periodontal index, follow-up studies, double-blind method, dental scaling, root planing, dietary supplements, adult, aged, middle aged, female, male, rank ligand, matrix metalloproteinase 8, chronic periodontitis
8 autores
- Hesham Mohamed El-Sharkawy🇪🇬Mansoura University
- Nayer S. AboElsaad🇪🇬Mansoura University
- Mohamed Eliwa🇪🇬Mansoura University
- Mahmoud Darweesh🇪🇬Mansoura University
- Mohammad Alshahat🇪🇬Mansoura University
- Alpdoğan Kantarcı🇺🇸Boston University
- Hatice Hastürk🇺🇸Boston University
- Thomas E. Van Dyke🇺🇸 · autor de correspondenciaBoston University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Host modulatory therapy has been proposed as a treatment for periodontal diseases. Omega-3 (ω-3) polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), were shown to have therapeutic anti-inflammatory and protective actions in inflammatory diseases including periodontitis. The goal of this study was to test an innovative strategy for periodontal treatment in a clinical experiment.
Methods
Eighty healthy subjects (40 in each group) with advanced chronic periodontitis were enrolled in Mansoura, Egypt, in a parallel-design, double-masked clinical study. The control group was treated with scaling and root planing (SRP) and a placebo, whereas the ω-3 group was treated with SRP followed by dietary supplementation of fish oil (900 mg EPA + DHA) and 81 mg aspirin daily. Saliva samples were obtained from all patients at baseline and 3 and 6 months for evaluation of receptor activator of nuclear factor-kappa B ligand (RANKL) and matrix metalloproteinase-8 (MMP-8). Plaque and gingival indices, bleeding on probing, probing depths, and attachment levels were recorded at the same time points.
Results
Statistical analyses demonstrated a significant reduction in probing depths and a significant attachment gain after 3 and 6 months in the ω-3 group compared to baseline and the control group (P <0.05). Salivary RANKL and MMP-8 levels showed significant reductions in the ω-3 group in response to treatment at 3 and 6 months and compared to the control group at 6 months (P <0.01). Supplementation with ω-3 + aspirin resulted in a significant shift in the frequency of pockets with probing depths <4 mm (P <0.05).
Conclusion
The results of this preliminary clinical study suggest that dietary supplementation with ω-3 PUFAs and 81 mg aspirin may provide a sustainable, low-cost intervention to augment periodontal therapy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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