Caffeine consumption and incident atrial fibrillation in women
Conen D, Chiuve SE, Everett BM, Zhang SM, Buring JE, Albert CM
The American journal of clinical nutrition · 67 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (HL-080467); National Heart, Lung, and Blood Institute (HL043851); National Cancer Institute (HL-043851); National Heart, Lung, and Blood Institute (R21 HL093613); National Cancer Institute (CA 047988); National Heart, Lung, and Blood Institute (HL080467); National Heart, Lung, and Blood Institute (CA047988)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-06-24 · Am J Clin Nutr · vol. 92 · número 3 · págs. 509–514
- Editorial
- Elsevier BV
- Citado
- 108 citas · más que el 94% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Atrial Fibrillation Management and Outcomes · Nutritional Studies and Diet
- Palabras clave
- caffeine consumption, atrial fibrillation, incident atrial fibrillation, women, coffee, tea, cola, chocolate, risk factors
- MeSH
- humans, atrial fibrillation, caffeine, plant extracts, data collection, incidence, proportional hazards models, follow-up studies, beverages, middle aged, female, surveys and questionnaires
6 autores
- David Conen🇺🇸🇨🇭 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; University Hospital of Basel
- Stephanie E. Chiuve🇺🇸🇨🇭Brigham and Women's Hospital; Harvard University; University Hospital of Basel
- Brendan M. Everett🇺🇸🇨🇭Brigham and Women's Hospital; Harvard University; University Hospital of Basel
- Shumin M. Zhang🇺🇸🇨🇭Brigham and Women's Hospital; Harvard University; University Hospital of Basel
- Julie E. Buring🇺🇸🇨🇭Brigham and Women's Hospital; Harvard University; University Hospital of Basel
- Christine M. Albert🇺🇸🇨🇭Brigham and Women's Hospital; Harvard University; University Hospital of Basel
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
It is somewhat controversial whether caffeine consumption is associated with an increased risk of developing atrial fibrillation (AF).
Objective
We prospectively assessed the relation between caffeine intake and incident AF.
Design
A total of 33,638 initially healthy women who participated in the Women's Health Study and who were gt 45 y of age and free of cardiovascular disease and AF at baseline were prospectively followed for incident AF from 1993 to 2 March 2009. All women provided information on caffeine intake via food-frequency questionnaires at baseline and in 2004.
Results
During a median follow-up of 14.4 y (interquartile range: 13.8-14.8 y), 945 AF events occurred. Median caffeine intakes across increasing quintiles of caffeine intake were 22, 135, 285, 402, and 656 mg/d, respectively. Age-adjusted incidence rates of AF across increasing quintiles of caffeine intake were 2.15, 1.89, 2.01, 2.24, and 2.04 events, respectively, per 1000 person-years of follow-up. In Cox proportional hazards models updated in 2004 by using time-varying covariates, the corresponding multivariable-adjusted hazard ratios (95% CI) were 1.0, 0.88 (0.72, 1.06), 0.78 (0.64, 0.95), 0.96 (0.79, 1.16), and 0.89 (0.73, 1.09) (P for linear trend: 0.45). None of the individual components of caffeine intake (coffee, tea, cola, and chocolate) were significantly associated with incident AF.
Conclusions
In this large cohort of initially healthy women, elevated caffeine consumption was not associated with an increased risk of incident AF. Therefore, our data suggest that elevated caffeine consumption does not contribute to the increasing burden of AF in the population. This trial was registered at clinicaltrials.gov as NCT00000479.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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