Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial
Cornelissen VA, Defoor JG, Stevens A, Schepers D, Hespel P, Decramer M, Mortelmans L, Dobbels F, Vanhaecke J, Fagard RH, Vanhees L
Clinical rehabilitation · 30 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-06-24 · Clin Rehabil · vol. 24 · número 11 · págs. 988–999
- Editorial
- SAGE Publishing
- Citado
- 51 citas · más que el 67% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Cardiac Health and Mental Health
- Palabras clave
- creatine supplementation, exercise training, cardiac rehabilitation, coronary artery disease, chronic heart failure, aerobic power, muscle strength, health-related quality of life, lipid profile, HDL cholesterol, triglycerides, adjuvant therapy
- MeSH
- humans, chronic disease, creatine, exercise test, chemotherapy, adjuvant, sickness impact profile, physical endurance, physical fitness, dietary supplements, middle aged, female, male, muscle strength, coronary artery disease, heart failure, resistance training
11 autores
- VA Cornelissen
- Johan Defoor
- A. Stevens
- Dirk Schepers
- Peter Hespel
- Marc Decramer
- L. Mortelmans
- Fabienne Dobbels
- Johan Vanhaecke
- RH Fagard
- Luc Vanhees🇧🇪 · autor de correspondenciaKU Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate the effect of oral creatine supplementation in conjunction with an exercise programme on physical fitness in patients with coronary artery disease or chronic heart failure.
Design
Single centre double-blind randomized placebo controlled trial.
Setting
Cardiac rehabilitation centre.
Subjects and intervention
70 (4 women) cardiac patients (age 57.5 (8.4) years) were randomized to a placebo (n = 37) or creatine (n = 33) treatment for three months. Combined aerobic endurance and resistance training (three sessions/ week) was performed during supplementation.
Main measures
Aerobic power was determined during graded bicycle testing, knee extensor peak isometric and isokinetic strength, endurance and recovery were assessed by an isokinetic dynamometer, and health related quality of life was evaluated with the SF-36 and MacNew Heart Disease questionnaires. In addition, blood samples were taken after an overnight fast and 24 hour urinary collection was performed.
Results
At baseline there were no significant differences between both groups. We observed main time effects for aerobic power, muscle performance, health related quality of life, high density lipoprotein cholesterol and triglycerides (pre vs post; P0.05). Further, no detrimental effect on renal or liver function was observed nor were there any reports of side effects.
Conclusion
Oral creatine supplementation in combination with exercise training does not exert any additional effect on the improvement in physical performance, health related quality of life, lipid profile in patients with coronary artery disease or chronic heart failure than exercise training alone.
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