Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis
Kalyani RR, Stein B, Valiyil R, Manno R, Maynard JW, Crews DC
Journal of the American Geriatrics Society · 144 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Public Health Service
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIAMS NIH HHS
- Gobierno
- PHS HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- U.S. Public Health Service (T32 90033122); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637); National Heart, Lung, and Blood Institute (K12-HL087169); National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32AR048522); National Center for Research Resources (KL2RR025006)
Según 10 financiadores declarados.
Publicación
- Publicado
- 2010-06-23 · J Am Geriatr Soc · vol. 58 · número 7 · págs. 1299–1310
- Editorial
- Wiley
- Citado
- 241 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, fall prevention, older adults, calcium supplementation, vitamin D3, fall risk, community-dwelling older adults, fracture history
- MeSH
- humans, vitamins, vitamin d, accidental falls, dietary supplements, aged, aged, 80 and over, female, male
6 autores
- Rita Rastogi Kalyani🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Brady Lee Stein
- Ritu Valiyil
- Rebecca Manno
- Janet W. Maynard
- Deidra C. Crews🇺🇸Johns Hopkins University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To systematically review and quantitatively synthesize the effect of vitamin D therapy on fall prevention in older adults.
Design
Systematic review and meta-analysis.
Setting
MEDLINE, CINAHL, Web of Science, EMBASE, Cochrane Library, LILACS, bibliographies of selected articles, and previous systematic reviews through February 2009 were searched for eligible studies.
Participants
Older adults (aged > or = 60) who participated in randomized controlled trials that both investigated the effectiveness of vitamin D therapy in the prevention of falls and used an explicit fall definition.
Measurements
Two authors independently extracted data, including study characteristics, quality assessment, and outcomes. The I(2) statistic was used to assess heterogeneity in a random-effects model.
Results
Of 1,679 potentially relevant articles, 10 met inclusion criteria. In pooled analysis, vitamin D therapy (200-1,000 IU) resulted in 14% (relative risk (RR)=0.86, 95% confidence interval (CI)=0.79-0.93; I(2)=7%) fewer falls than calcium or placebo (number needed to treat =15). The following subgroups had significantly fewer falls: community-dwelling (aged <80), adjunctive calcium supplementation, no history of fractures or falls, duration longer than 6 months, cholecalciferol, and dose of 800 IU or greater. Meta-regression demonstrated no linear association between vitamin D dose or duration and treatment effect. Post hoc analysis including seven additional studies (17 total) without explicit fall definitions yielded smaller benefit (RR=0.92, 95% CI=0.87-0.98) and more heterogeneity (I(2)=36%) but found significant intergroup differences favoring adjunctive calcium over none (P=.001).
Conclusion
Vitamin D treatment effectively reduces the risk of falls in older adults. Future studies should investigate whether particular populations or treatment regimens may have greater benefit.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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