Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain
Rawson ES, Stec MJ, Frederickson SJ, Miles MP
Nutrition (Burbank, Los Angeles County, Calif.) · 30 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-07-02 · Nutrition · vol. 27 · número 4 · págs. 451–455
- Editorial
- Elsevier BV
- Citado
- 58 citas · más que el 83% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Sports Performance and Training
- Palabras clave
- creatine supplementation, fatigue resistance, muscle fatigue, plasma creatine, body composition, fat-free mass, maximal strength, knee extension, weight gain
- MeSH
- muscle, skeletal, humans, body weight, creatine, double-blind method, muscle fatigue, muscle contraction, dietary supplements, adult, female, male, young adult
4 autores
- Eric S. Rawson🇺🇸 · autor de correspondenciaBloomsburg University
- Michael J. Stec🇺🇸Bloomsburg University
- Sara J. Frederickson🇺🇸Montana State University
- Mary P. Miles🇺🇸Montana State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We examined the effects of 6 wk of low-dose creatine supplementation on body composition, muscle function, and body creatine retention.
Methods
Twenty healthy men and women (21 ± 2 y old) were randomized to receive creatine (0.03 g · kg(-1) · d(-1); n = 10, 4 women) or placebo (n = 10, 4 women) for 6 wk in a double-blind placebo-controlled fashion. Participants were tested on two occasions before supplementation to establish a reliable baseline, and then were retested after supplementation. Testing included body composition, maximal strength (three-repetition maximal concentric knee extension at 180 degrees/s), muscle fatigue (five sets of 30 concentric knee extensions at 180 degrees/s), and plasma creatine concentration.
Results
There were no significant differences in body mass, fat-free mass, fat mass, body fat percentage, total body water, or maximal strength in either group from before to after supplementation (all P > 0.05). After supplementation, plasma creatine increased significantly in the creatine group (+182%, P = 0.03), with no difference in the placebo group. Compared with baseline values, creatine-supplemented volunteers were more resistant to fatigue during sets 2 (7%), 3 (9%), 4 (9%), and 5 (11%) (all P 0.05).
Conclusion
Ingesting a low dose (≈2.3 g/d) of creatine for 6 wk significantly increased plasma creatine concentration and enhanced resistance to fatigue during repeated bouts of high-intensity contractions.
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