Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: a double-blind, placebo-controlled, randomized clinical trial
Rondanelli M, Giacosa A, Opizzi A, Pelucchi C, La Vecchia C, Montorfano G, Negroni M, Berra B, Politi P, Rizzo AM
Journal of the American College of Nutrition · 79 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Regione Lombardia
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-02-01 · J Am Coll Nutr · vol. 29 · número 1 · págs. 55–64
- Editorial
- Taylor & Francis
- Citado
- 118 citas · más que el 98% de estudios similares · 8.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Treatment of Major Depression · Tryptophan and brain disorders
- Palabras clave
- omega-3 fatty acids, long-chain polyunsaturated fatty acids, depression, older women, health-related quality of life, eicosapentaenoic acid, docosahexaenoic acid, dietary supplementation, nursing home residents, erythrocyte membrane phospholipids, Geriatric Depression Scale, SF-36
- MeSH
- erythrocytes, cell membrane, humans, docosahexaenoic acids, eicosapentaenoic acid, phospholipids, double-blind method, depression, patient compliance, depressive disorder, quality of life, dietary supplements, aged, aged, 80 and over, female, male
10 autores
- Mariangela Rondanelli🇮🇹 · autor de correspondenciaUniversity of Pavia; Azienda di Servizi alla Persona di Pavia (Italy)
- Attilio Giacosa
- Annalisa Opizzi🇮🇹Mario Negri Institute for Pharmacological Research
- Claudio Pelucchi🇮🇹Mario Negri Institute for Pharmacological Research
- Carlo La Vecchia🇮🇹Mario Negri Institute for Pharmacological Research
- Gigliola Montorfano🇮🇹University of Milan
- Manuela Negroni🇮🇹University of Milan
- Bruno Berra🇮🇹University of Milan
- Pierluigi Politi🇮🇹University of Pavia
- Angela Maria Rizzo🇮🇹University of Milan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
In elderly individuals, depression is one of the most frequently missed diagnoses with negative effects on quality of life. The authors investigated whether a supplement containing long-chain omega-3 polyunsaturated fatty acids (n-3 LCPUFA) improves depressive symptoms and health-related quality of life (HRQoL) in depressed elderly patients.
Design
Eight-week, randomized, double-blind, placebo-controlled trial.
Setting
Nursing home in Pavia, Italy.
Participants
Forty-six depressed women, aged 66-95 years.
Intervention
Twenty-two depressed women were included in the intervention group (n-3 group, which received 2.5 g/d of n-3 LCPUFA, with 1.67 g of eicosapentaenoic acid [EPA] and 0.83 g of docosahesaenoic acid [DHA]), and 24 patients were included in the placebo group. The primary endpoint was the improvement of depressive symptoms, as evaluated by the Geriatric Depression Scale (GDS). Secondary endpoints were the evaluation of HRQoL, by using the Short-Form 36-Item Health Survey (SF-36), and modifications of erythrocyte membrane phospholipids fatty acid profile. All variables were assessed before and after the treatment period of 8 weeks.
Results
The mean GDS at 8 weeks was significantly lower compared with the n-3 group. The SF-36 physical and mental components were significantly increased in the intervention group. Compliance was good, as confirmed by erythrocyte membrane phospholipid FA concentrations, with a significant increase of EPA and DHA in the intervention group.
Conclusion
Supplementation with n-3 LCPUFA is efficacious in the amelioration of depressive symptoms and quality of life in the treatment of depressed elderly female patients.
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