Financiado en parte por Egg Nutrition Center
Daily egg consumption in hyperlipidemic adults--effects on endothelial function and cardiovascular risk
Njike V, Faridi Z, Dutta S, Gonzalez-Simon AL, Katz DL
Nutrition journal · 48 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Egg Nutrition Center
- Gobierno
- Centers for Disease Control and Prevention
- Gobierno
- U.S. Public Health Service
- Gobierno
- PHS HHS
- Subvenciones
- U.S. Public Health Service (U48-CCU115802)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2010-07-02 · Nutr J · vol. 9 · número 1 · pág. 28
- Editorial
- BioMed Central
- Citado
- 72 citas · más que el 96% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Lipoproteins and Cardiovascular Health · Cardiovascular Health and Disease Prevention
- Palabras clave
- egg consumption, hyperlipidemia, endothelial function, flow-mediated dilation, dietary cholesterol, serum cholesterol, LDL cholesterol, egg substitutes, cardiovascular risk, dietary fat
- MeSH
- brachial artery, endothelium, humans, cardiovascular diseases, cholesterol, cholesterol, dietary, endothelins, ultrasonography, doppler, diet, risk, eggs, adult, aged, middle aged, female, male, nitric oxide synthase type iii, hyperlipidemias
5 autores
- Valentine Yanchou Njike🇺🇸Yale University; Yale Griffin Prevention Research Center
- Zubaida Faridi🇺🇸Yale University; Yale Griffin Prevention Research Center
- Suparna Dutta🇺🇸Griffin Hospital
- Anjelica L. Gonzalez-Simon🇺🇸Yale University
- David L. Katz🇺🇸 · autor de correspondenciaYale University; Yale Griffin Prevention Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Limiting consumption of eggs, which are high in cholesterol, is generally recommended to reduce risk of cardiovascular disease. However, recent evidence suggests that dietary cholesterol has limited influence on serum cholesterol or cardiac risk.
Objective
To assess the effects of egg consumption on endothelial function and serum lipids in hyperlipidemic adults.
Methods
Randomized, placebo-controlled crossover trial of 40 hyperlipidemic adults (24 women, 16 men; average age = 59.9 +/- 9.6 years; weight = 76.3 +/- 21.8 kilograms; total cholesterol = 244 +/- 24 mg/dL). In the acute phase, participants were randomly assigned to one of the two sequences of a single dose of three medium hardboiled eggs and a sausage/cheese breakfast sandwich. In the sustained phase, participants were then randomly assigned to one of the two sequences of two medium hardboiled eggs and 1/2 cup of egg substitute daily for six weeks. Each treatment assignment was separated by a four-week washout period. Outcome measures of interest were endothelial function measured as flow mediated dilatation (FMD) and lipid panel.
Results
Single dose egg consumption had no effects on endothelial function as compared to sausage/cheese (0.4 +/- 1.9 vs. 0.4 +/- 2.4%; p = 0.99). Daily consumption of egg substitute for 6 weeks significantly improved endothelial function as compared to egg (1.0 +/- 1.2% vs. -0.1 +/- 1.5%; p < 0.01) and lowered serum total cholesterol (-18 +/- 18 vs. -5 +/- 21 mg/dL; p < 0.01) and LDL (-14 +/- 20 vs. -2 +/- 19 mg/dL; p = 0.01). Study results (positive or negative) are expressed in terms of change relative to baseline.
Conclusions
Egg consumption was found to be non-detrimental to endothelial function and serum lipids in hyperlipidemic adults, while egg substitute consumption was beneficial.
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