Effect of caffeine on ibuprofen analgesia in postoperative oral surgery pain
Forbes JA, Beaver WT, Jones KF, Kehm CJ, Smith WK, Gongloff CM, Zeleznock JR, Smith JW
Clinical pharmacology and therapeutics · 46 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1991-06-01 · Clin Pharmacol Ther · vol. 49 · número 6 · págs. 674–684
- Editorial
- Wiley
- Citado
- 75 citas · más que el 87% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Anesthesia and Pain Management · Pain Management and Opioid Use · Pain Mechanisms and Treatments
- Palabras clave
- caffeine, ibuprofen, adjuvant analgesics, postoperative pain, oral surgery, impacted third molar extraction, nonsteroidal anti-inflammatory drugs, analgesic potency, onset and duration of analgesia
- MeSH
- humans, ibuprofen, caffeine, drug therapy, combination, postoperative care, analgesia, tooth extraction, analysis of variance, dentistry, operative, time factors, adolescent, adult, middle aged, female, male, postoperative pain
8 autores
- James Alexander Forbes🇺🇸 · autor de correspondenciaJohns Hopkins University; Georgetown University; Johns Hopkins Medicine
- William T. Beaver🇺🇸Johns Hopkins University; Georgetown University; Johns Hopkins Medicine
- Katherine F. Jones🇺🇸Johns Hopkins University; Georgetown University; Johns Hopkins Medicine
- Carolyn J. Kehm🇺🇸Johns Hopkins University; Georgetown University; Johns Hopkins Medicine
- W. K. Smith🇺🇸Johns Hopkins University; Georgetown University; Johns Hopkins Medicine
- Charles M. Gongloff🇺🇸Johns Hopkins University; Georgetown University; Johns Hopkins Medicine
- John R. Zeleznock🇺🇸Johns Hopkins University; Georgetown University; Johns Hopkins Medicine
- John W. Smith🇺🇸Johns Hopkins University; Georgetown University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Recent studies have demonstrated that caffeine acts as an analgesic adjuvant when combined with acetaminophen, aspirin, or their mixture. Our objective was to determine whether similar enhancement of analgesia could be demonstrated when caffeine is combined with ibuprofen. On a double-blind basis, a single oral dose of ibuprofen (50, 100, or 200 mg), a combination of ibuprofen, 100 mg, with caffeine, 100 mg, a combination of ibuprofen, 200 mg, with caffeine, 100 mg, or placebo was randomly assigned to 298 outpatients with postoperative pain after the surgical removal of impacted third molars. With a self-rating record, subjects rated their pain and its relief hourly for 8 hours. All active treatments were significantly superior to placebo, and the caffeine effect was significant for every measure of analgesia. Relative potency estimates indicated that the combination was 2.4 to 2.8 times as potent as ibuprofen alone. The combination also had a more rapid onset and longer duration of analgesic action. The analgesic adjuvancy of caffeine clearly extends to combinations with nonsteroidal anti-inflammatory drugs other than acetaminophen or aspirin.
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