Vitamin D and risk of cognitive decline in elderly persons
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D
Archives of internal medicine · 283 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Organización sin fines de lucro
- Vivensa Foundation
- Gobierno
- Medical Research Council
- Subvenciones
- National Institute on Aging (R01AG027010)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-07-12 · Arch Intern Med · vol. 170 · número 13 · pág. 1135
- Editorial
- American Medical Association
- Citado
- 459 citas · más que el 100% de estudios similares · 29.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- vitamin D, 25-hydroxyvitamin D, vitamin D deficiency, cognitive decline, dementia, older adults, InCHIANTI cohort, Trail Making Test, Mini-Mental State Examination, serum vitamin D levels
- MeSH
- humans, vitamin d deficiency, vitamins, vitamin d, radioimmunoassay, prognosis, population surveillance, incidence, risk factors, follow-up studies, prospective studies, cognition, cognition disorders, time factors, aged, italy, female, male
1 autor
- David J. Llewellyn🇬🇧 · autor de correspondenciaUniversity of Exeter; Royal Devon and Exeter Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia.
Methods
We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population-based study conducted in Italy between 1998 and 2006 with follow-up assessments every 3 years. A total of 858 adults 65 years or older completed interviews, cognitive assessments, and medical examinations and provided blood samples. Cognitive decline was assessed using the Mini-Mental State Examination (MMSE), and substantial decline was defined as 3 or more points. The Trail-Making Tests A and B were also used, and substantial decline was defined as the worst 10% of the distribution of decline or as discontinued testing.
Results
The multivariate adjusted relative risk (95% confidence interval [CI]) of substantial cognitive decline on the MMSE in participants who were severely serum 25(OH)D deficient (levels /=75 nmol/L) was 1.60 (95% CI, 1.19-2.00). Multivariate adjusted random-effects models demonstrated that the scores of participants who were severely 25(OH)D deficient declined by an additional 0.3 MMSE points per year more than those with sufficient levels of 25(OH)D. The relative risk for substantial decline on Trail-Making Test B was 1.31 (95% CI, 1.03-1.51) among those who were severely 25(OH)D deficient compared with those with sufficient levels of 25(OH)D. No significant association was observed for Trail-Making Test A.
Conclusion
Low levels of vitamin D were associated with substantial cognitive decline in the elderly population studied over a 6-year period, which raises important new possibilities for treatment and prevention.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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